Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHOA | P61586 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9835980 | 1.00 | RHOA (0.53) | RHOAALDH1A1L3MBTL1POLBKDM4E | |
| SCHEMBL3179354 | 0.85 | SRD5A2 (0.56) | RHOAALDH1A1L3MBTL1KDM4ESMN1; SMN2 | |
| SCHEMBL3179345 | 0.85 | SRD5A2 (0.56) | RHOAALDH1A1L3MBTL1KDM4ESMN1; SMN2 | |
| SCHEMBL10666158 | 0.84 | ALDH1A1 (0.70) | RHOAALDH1A1L3MBTL1POLBKDM4E | |
| SCHEMBL10666146 | 0.84 | ALDH1A1 (0.70) | RHOAALDH1A1L3MBTL1POLBKDM4E | |
| SCHEMBL3618167 | 0.84 | ALDH1A1 (0.65) | ALDH1A1L3MBTL1KDM4ESMN1; SMN2P4HTM | |
| SCHEMBL3618165 | 0.84 | ALDH1A1 (0.65) | ALDH1A1L3MBTL1KDM4ESMN1; SMN2P4HTM | |
| SCHEMBL510406 | 0.81 | ALDH1A1 (0.69) | ALDH1A1L3MBTL1POLBKDM4EKMT2A | |
| SCHEMBL28893686 | 0.80 | KDM4E (0.58) | RHOAALDH1A1POLBKDM4ESMN1; SMN2 | |
| SCHEMBL28893595 | 0.80 | KDM4E (0.58) | RHOAALDH1A1POLBKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0210782-B1 | PYRIDINE COMPOUNDS, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | Dainippon Pharmaceutical Co., Ltd. (JP) | 1991-04-17 | — | — | EP | disclosed |
| US-4778796-A | ω-(3-pyridyl)alkenamide derivatives and anti-allergenic pharmaceutical compositions containing same | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1988-10-18 | — | — | US | disclosed |
| EP-0210782-A2 | Pyridine compounds, process for the preparation thereof and pharmaceutical composition containing the same | Dainippon Pharmaceutical Co., Ltd. (JP) | 1987-02-04 | — | — | EP | disclosed |