Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 12/20 | 0.69 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4761629 | 0.82 | PARP1 (1.00) | PARP1 | |
| SCHEMBL5522439 | 0.82 | PARP1 (1.00) | PARP1 | |
| SCHEMBL9836935 | 0.81 | PARP1 (0.97) | PARP1 | |
| SCHEMBL5527862 | 0.70 | PARP1 (0.68) | PARP1 | |
| SCHEMBL4792310 | 0.69 | PARP1 (0.56) | PARP1 | |
| SCHEMBL4763087 | 0.68 | PARP1 (0.63) | PARP1 | |
| SCHEMBL4792007 | 0.67 | PARP1 (0.57) | PARP1 | |
| SCHEMBL2193298 | 0.66 | PARP1 (0.54) | PARP1 | |
| SCHEMBL5523765 | 0.65 | PARP1 (0.59) | PARP1 | |
| SCHEMBL4724958 | 0.65 | PARP1 (0.63) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0104522-B1 | NEW PYRAZOLO(3,4-B)PYRIDINE DERIVATIVES AND PROCESS FOR PRODUCING THEM | GRUPPO LEPETIT S.p.A. (IT) | 1991-05-29 | — | — | EP | disclosed |
| US-4612318-A | CNS-depressant and analgesic tricyclo-[pyrazolo-[3,4-6]-pyridine] derivatives and pharmaceutical compositions thereof | GRUPPO LEPETIT S.P.A. (IT) | 1986-09-16 | — | — | US | disclosed |
| EP-0104522-A2 | New pyrazolo(3,4-b)pyridine derivatives and process for producing them | GRUPPO LEPETIT S.p.A. (IT) | 1984-04-04 | — | — | EP | disclosed |