⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7560144 | 0.83 | — | — | |
| Nitric Acid SCHEMBL2976545 | 0.81 | CA5A (0.40) | — | |
| SCHEMBL12804836 | 0.79 | — | — | |
| SCHEMBL19052821 | 0.78 | — | — | |
| SCHEMBL401651 | 0.78 | — | — | |
| SCHEMBL13912783 | 0.77 | — | — | |
| SCHEMBL863692 | 0.76 | MAPT (0.44) | — | |
| SCHEMBL11883060 | 0.76 | MAPT (0.44) | — | |
| SCHEMBL2760377 | 0.76 | MAPT (0.39) | — | |
| SCHEMBL3000825 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0167008-B1 | 1,4:3,6-DIANHYDRO-HEXITE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | Heinrich Mack Nachf. (DE) | 1989-09-06 | — | — | EP | claimed |
| US-4769379-A | Dianhydrohexite derivatives, and their use as pharmaceuticals | HEINRICH MACK NACHF. (DE) | 1988-09-06 | — | — | US | claimed |
| EP-0234494-B1 | ISOHEXIDE NUCLEOSIDES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | Heinrich Mack Nachf. (DE) | 1991-03-13 | — | — | EP | disclosed |
| EP-0167008-B1 | 1,4:3,6-DIANHYDRO-HEXITE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | Heinrich Mack Nachf. (DE) | 1989-09-06 | — | — | EP | disclosed |
| US-4806542-A | VIRISTATICS, IMMUNOSTIMULANTS | HEINRICH MACK NACHF. (DE) | 1989-02-21 | — | — | US | disclosed |
| US-4769379-A | Dianhydrohexite derivatives, and their use as pharmaceuticals | HEINRICH MACK NACHF. (DE) | 1988-09-06 | — | — | US | disclosed |
| EP-0234494-A2 | Isohexide nucleosides, processes for their preparation and their use as medicaments | Heinrich Mack Nachf. (DE) | 1987-09-02 | — | — | EP | disclosed |
| EP-0114270-B1 | ACYL DERIVATIVES OF 1,4:3,6-DIANHYDRO-HEXITOLES, METHOD FOR THEIR PREPARATION AND THEIR PHARMAZEUTICAL USE | Heinrich Mack Nachf. (DE) | 1987-04-01 | — | — | EP | disclosed |
| EP-0167008-A2 | 1,4:3,6-Dianhydro-hexite derivatives, process for their preparation and their use as medicaments | Heinrich Mack Nachf. (DE) | 1986-01-08 | — | — | EP | disclosed |
| EP-0167008-A2 | 1,4:3,6-Dianhydro-hexite derivatives, process for their preparation and their use as medicaments | Heinrich Mack Nachf. (DE) | 1986-01-08 | — | — | EP | disclosed |
| EP-0114270-A1 | Acyl derivatives of 1,4:3,6-dianhydro-hexitoles, method for their preparation and their pharmazeutical use | Heinrich Mack Nachf. (DE) | 1984-08-01 | — | — | EP | disclosed |