Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GART | P22102 | 5/20 | 0.59 |
| ▸ | SOST | Q9BQB4 | 1/20 | 0.56 |
| ▸ | ATIC | P31939 | 3/20 | 0.55 |
| ▸ | DHFR | P00374 | 1/20 | 0.52 |
| ▸ | MTHFD1 | P11586 | 3/20 | 0.51 |
| ▸ | FPGS | Q05932 | 2/20 | 0.49 |
| ▸ | MTHFD2 | P13995 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10512730 | 0.88 | GART (0.78) | GARTSOSTATICDHFRMTHFD1 | |
| SCHEMBL10512772 | 0.88 | GART (0.78) | GARTSOSTATICDHFRMTHFD1 | |
| SCHEMBL9837105 | 0.87 | GART (0.77) | GARTSOSTATICDHFRMTHFD1 | |
| SCHEMBL10519237 | 0.86 | GART (0.44) | GARTSOSTATICDHFRMTHFD1 | |
| SCHEMBL9836207 | 0.86 | GART (0.44) | GARTSOSTATICDHFRMTHFD1 | |
| SCHEMBL12421755 | 0.81 | GART (0.65) | GARTSOSTATICDHFRMTHFD1 | |
| SCHEMBL10512755 | 0.80 | GART (0.61) | GARTSOSTATICDHFRMTHFD1 | |
| SCHEMBL29692685 | 0.79 | GART (0.65) | GARTSOSTATICDHFRMTHFD1 | |
| SCHEMBL29692334 | 0.79 | FPGS (0.72) | GARTSOSTATICDHFRMTHFD1 | |
| SCHEMBL9836738 | 0.77 | GART (0.73) | GARTSOSTATICDHFRMTHFD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0255228-B1 | 4(3H)-OXO-5,6,7,8,-TETRAHYDROPYRIDO-(2,3-D)PYRIMIDINE DERIVATIVES | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1991-05-02 | — | — | EP | disclosed |