Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GART | P22102 | 5/20 | 0.44 |
| ▸ | ATIC | P31939 | 1/20 | 0.41 |
| ▸ | SOST | Q9BQB4 | 1/20 | 0.41 |
| ▸ | FPGS | Q05932 | 2/20 | 0.40 |
| ▸ | DHFR | P00374 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MTHFD1 | P11586 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10519237 | 1.00 | GART (0.44) | GARTATICSOSTFPGSDHFR | |
| SCHEMBL10512971 | 0.89 | GART (0.58) | GARTATICDHFRKDM4EALDH1A1 | |
| SCHEMBL9836773 | 0.87 | GART (0.43) | GARTATICDHFRKDM4EALDH1A1 | |
| SCHEMBL9837156 | 0.86 | GART (0.59) | GARTATICSOSTFPGSDHFR | |
| SCHEMBL9836685 | 0.81 | GART (0.42) | GARTATICDHFRKDM4EALDH1A1 | |
| SCHEMBL9837146 | 0.80 | GART (0.41) | GARTATICDHFRKDM4EALDH1A1 | |
| SCHEMBL9534086 | 0.75 | GART (0.49) | GARTATICDHFRKDM4EALDH1A1 | |
| SCHEMBL9534079 | 0.75 | GART (0.49) | GARTATICDHFRKDM4EALDH1A1 | |
| SCHEMBL10494144 | 0.74 | KDM4E (0.40) | GARTATICDHFRKDM4EALDH1A1 | |
| SCHEMBL10494147 | 0.74 | KDM4E (0.40) | GARTATICDHFRKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0255228-B1 | 4(3H)-OXO-5,6,7,8,-TETRAHYDROPYRIDO-(2,3-D)PYRIMIDINE DERIVATIVES | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1991-05-02 | — | — | EP | disclosed |
| US-4833145-A | 4(3H)-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidine derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1989-05-23 | — | — | US | disclosed |