Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.53 |
| ▸ | TOP1 | P11387 | 9/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9837357 | 0.91 | KDM4E (0.60) | KDM4EHPGDALDH1A1HSD17B10PMP22 | |
| SCHEMBL9838745 | 0.87 | KDM4E (0.56) | KDM4EHPGDALDH1A1HSD17B10PMP22 | |
| SCHEMBL9838719 | 0.85 | KDM4E (0.59) | KDM4EHPGDALDH1A1HSD17B10PMP22 | |
| SCHEMBL9838607 | 0.82 | KDM4E (0.57) | KDM4EHPGDALDH1A1HSD17B10PMP22 | |
| SCHEMBL9837339 | 0.81 | TOP2A (0.49) | KDM4EHPGDALDH1A1HSD17B10LMNA | |
| SCHEMBL9838758 | 0.80 | KDM4E (0.48) | KDM4EHPGDALDH1A1HSD17B10PMP22 | |
| SCHEMBL9837602 | 0.80 | HSD17B10 (0.64) | KDM4EHPGDALDH1A1HSD17B10PMP22 | |
| SCHEMBL9838764 | 0.79 | KDM4E (0.59) | KDM4EHPGDALDH1A1HSD17B10PMP22 | |
| SCHEMBL9837294 | 0.78 | KDM4E (0.64) | KDM4EHPGDALDH1A1HSD17B10PMP22 | |
| SCHEMBL9838688 | 0.78 | TOP2A (0.47) | KDM4EHPGDALDH1A1HSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0159174-B1 | SUBSTITUTED NAPHTHYRIDINE-, QUINOLINE- AND BENZOXAZINE- CARBOXYLIC ACIDS AS ANTIBACTERIAL AGENTS AND PROCESSES FOR THEIR PRODUCTION | WARNER-LAMBERT COMPANY (US) | 1991-10-23 | — | — | EP | disclosed |
| US-4571396-A | Antibacterial agents | WARNER-LAMBERT COMPANY (US) | 1986-02-18 | — | — | US | disclosed |
| EP-0159174-A2 | Substituted naphthyridine-, quinoline- and benzoxazine- carboxylic acids as antibacterial agents and processes for their production | WARNER-LAMBERT COMPANY (US) | 1985-10-23 | — | — | EP | disclosed |