Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | AADAT | Q8N5Z0 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | ALB | P02768 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | TOP1 | P11387 | 6/20 | 0.39 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TUBB | P07437 | 1/20 | 0.39 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.39 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.39 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.39 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.39 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.39 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.39 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.39 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9837629 | 0.89 | PIM1 (0.45) | AADATKDM4EALDH1A1HPGDHSD17B10 | |
| Hydrochloric Acid SCHEMBL9839219 | 0.88 | PIM1 (0.44) | AADATKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL4195115 | 0.85 | KCNH2 (0.42) | KCNH2AADATKDM4EALDH1A1HPGD | |
| SCHEMBL9839682 | 0.84 | KDM4E (0.43) | KCNH2AADATKDM4EALDH1A1HPGD | |
| SCHEMBL10764531 | 0.84 | AADAT (0.38) | AADATKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9838924 | 0.83 | KDM4E (0.38) | AADATKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9837891 | 0.83 | KDM4E (0.56) | AADATKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9839287 | 0.83 | KDM4E (0.45) | AADATKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9839648 | 0.82 | AADAT (0.41) | AADATKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9838873 | 0.80 | AADAT (0.41) | KCNH2AADATKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0228661-B1 | ISOXAZOLO-PYRIDO-BENZOXAZINE AND ISOTHIAZOLO-PYRIDO-BENZOXAZINE DERIVATIVES | ABBOTT LABORATORIES (US) | 1991-08-07 | — | — | EP | disclosed |
| US-4687770-A | Isoxazolo-pyrido-benzoxazine and isothiazolo-pyrido-benzoxazine derivatives | ABBOTT LABORATORIES (US) | 1987-08-18 | — | — | US | disclosed |
| EP-0228661-A1 | Isoxazolo-pyrido-benzoxazine and isothiazolo-pyrido-benzoxazine derivatives | ABBOTT LABORATORIES (US) | 1987-07-15 | — | — | EP | disclosed |