Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HSPA5 | P11021 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | HSPA2 | P54652 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9838903 | 0.93 | RAB9A (0.40) | NPC1RAB9AHPGDSMN1; SMN2HSPA5 | |
| SCHEMBL9839261 | 0.92 | NPC1 (0.40) | NPC1RAB9AHPGDSMN1; SMN2HSPA5 | |
| SCHEMBL9605133 | 0.92 | RAB9A (0.38) | NPC1RAB9AHPGDSMN1; SMN2HTT | |
| SCHEMBL10518993 | 0.92 | NPC1 (0.40) | NPC1RAB9AHPGDSMN1; SMN2HSPA5 | |
| SCHEMBL10524820 | 0.91 | HSPA5 (0.40) | NPC1RAB9AHPGDSMN1; SMN2HSPA5 | |
| SCHEMBL9837932 | 0.90 | NPC1 (0.42) | NPC1RAB9AHPGDSMN1; SMN2HSPA5 | |
| SCHEMBL10665065 | 0.89 | HTT (0.40) | NPC1RAB9AHPGDSMN1; SMN2HSPA5 | |
| SCHEMBL9839266 | 0.87 | HTT (0.39) | NPC1RAB9AHPGDSMN1; SMN2HSPA5 | |
| SCHEMBL10667122 | 0.87 | KDM4E (0.40) | HSPA5HSPA2ALOX15MAPK1KMT2A | |
| SCHEMBL9837900 | 0.87 | HSPA5 (0.43) | NPC1RAB9AHPGDSMN1; SMN2HSPA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4988708-A | 3-Carbamoyl-4-hydroxy-2-carboxylmethyl quinoline analgesics, antiinflammatory agents | ROUSSEL UCLAF (FR) | 1991-01-29 | — | — | US | disclosed |
| US-4845105-A | 4-OH-quinoline carboxylic acid amides having analgesic and anti-inflammatory activity | ROUSSEL UCLAF (FR) | 1989-07-04 | — | — | US | disclosed |
| US-4735951-A | Novel 4-hydroxy-3-quinoline-carboxylates having analgesic and anti-inflammatory activity | ROUSSEL UCLAF (FR) | 1988-04-05 | — | — | US | disclosed |
| EP-0183584-A1 | Esters of derivatives of 2-alpha-hydroxy-substituted 4-hydroxy-3-quinoline carboxylic acid, their preparation, their use as medicaments and compositions containing them | ROUSSEL-UCLAF (FR) | 1986-06-04 | — | — | EP | disclosed |