Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.39 |
| ▸ | BLM | P54132 | 2/20 | 0.38 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.37 |
| ▸ | HTR2C | P28335 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9838912 | 0.99 | CYP19A1 (0.42) | CYP19A1SLC6A3CHRM2BLMPABPC1 | |
| SCHEMBL10379822 | 0.86 | CYP19A1 (0.47) | CYP19A1SLC6A3CHRM2BLMPABPC1 | |
| SCHEMBL10378520 | 0.84 | CYP19A1 (0.45) | CYP19A1SLC6A3CHRM2BLMPABPC1 | |
| SCHEMBL10379311 | 0.82 | CYP19A1 (0.43) | CYP19A1SLC6A3CHRM2BLMPABPC1 | |
| SCHEMBL10379344 | 0.78 | CYP19A1 (0.69) | CYP19A1SLC6A3CHRM2BLMCHRM5 | |
| SCHEMBL9837852 | 0.78 | CYP19A1 (0.44) | CYP19A1SLC6A3TSHRSMN1; SMN2 | |
| SCHEMBL10379334 | 0.77 | CYP19A1 (0.67) | CYP19A1SLC6A3CHRM2BLMCHRM5 | |
| SCHEMBL9837529 | 0.76 | CYP19A1 (0.42) | CYP19A1SLC6A3CHRM2BLMCHRM5 | |
| SCHEMBL10379790 | 0.76 | LMNA (0.41) | SLC6A3CHRM2BLMPABPC1CYP2C19 | |
| SCHEMBL9838823 | 0.75 | EPHX1 (0.50) | MEN1KMT2ALMNANFKB1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0276122-B1 | CYCLOALKYL-SUBSTITUTED 4-AMINOPHENYL HALO DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.r.l. (IT) | 1991-08-07 | — | — | EP | disclosed |
| US-4847295-A | ANTITUMOR AGENTS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1989-07-11 | — | — | US | disclosed |
| EP-0276122-A2 | Cycloalkyl-substituted 4-aminophenyl halo derivatives and process for their preparation | FARMITALIA CARLO ERBA S.r.l. (IT) | 1988-07-27 | — | — | EP | disclosed |