Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 15/20 | 0.41 |
| ▸ | TOP2B | Q02880 | 10/20 | 0.41 |
| ▸ | TOP1 | P11387 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.38 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9839667 | 0.99 | TOP2A (0.40) | TOP2ATOP2BTOP1ALDH1A1POLB | |
| SCHEMBL9839307 | 0.85 | AADAT (0.33) | ALDH1A1POLB | |
| SCHEMBL9837703 | 0.85 | KDM4E (0.42) | ALDH1A1POLBOPRM1 | |
| SCHEMBL9839117 | 0.84 | TOP2A (0.40) | TOP2ATOP2BTOP1ALDH1A1POLB | |
| SCHEMBL10729692 | 0.84 | TOP2A (0.37) | TOP2ATOP2BTOP1ALDH1A1POLB | |
| Hydrochloric Acid SCHEMBL9839687 | 0.83 | TOP2A (0.39) | TOP2ATOP2BTOP1ALDH1A1POLB | |
| SCHEMBL9839234 | 0.83 | KDM4E (0.44) | TOP2ATOP1ALDH1A1POLB | |
| SCHEMBL9837629 | 0.82 | PIM1 (0.45) | TOP2ATOP2BTOP1ALDH1A1POLB | |
| Hydrochloric Acid SCHEMBL9839219 | 0.81 | PIM1 (0.44) | TOP2ATOP2BTOP1ALDH1A1POLB | |
| SCHEMBL9825021 | 0.79 | PIM1 (0.43) | TOP2ATOP2BTOP1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0228661-B1 | ISOXAZOLO-PYRIDO-BENZOXAZINE AND ISOTHIAZOLO-PYRIDO-BENZOXAZINE DERIVATIVES | ABBOTT LABORATORIES (US) | 1991-08-07 | — | — | EP | disclosed |
| US-4687770-A | Isoxazolo-pyrido-benzoxazine and isothiazolo-pyrido-benzoxazine derivatives | ABBOTT LABORATORIES (US) | 1987-08-18 | — | — | US | disclosed |
| EP-0228661-A1 | Isoxazolo-pyrido-benzoxazine and isothiazolo-pyrido-benzoxazine derivatives | ABBOTT LABORATORIES (US) | 1987-07-15 | — | — | EP | disclosed |