Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | PRKX | P51817 | 1/20 | 0.37 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.37 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.37 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9839145 | 0.89 | NPC1 (0.40) | NPC1RAB9AALDH1A1KDM4ELMNA | |
| SCHEMBL9838903 | 0.85 | RAB9A (0.40) | NPC1RAB9ALMNAMAPTHTT | |
| SCHEMBL10664235 | 0.83 | NPC1 (0.47) | NPC1RAB9AALDH1A1KDM4ELMNA | |
| SCHEMBL10946310 | 0.83 | NPC1 (0.47) | NPC1RAB9AALDH1A1KDM4ELMNA | |
| SCHEMBL9839093 | 0.81 | NPC1 (0.42) | NPC1RAB9AALDH1A1KDM4ELMNA | |
| SCHEMBL9838204 | 0.80 | KDM4E (0.43) | NPC1RAB9AALDH1A1KDM4ELMNA | |
| SCHEMBL10518993 | 0.79 | NPC1 (0.40) | NPC1RAB9ALMNAHTTSMN1; SMN2 | |
| SCHEMBL10524820 | 0.79 | HSPA5 (0.40) | NPC1RAB9ALMNAHTTMEN1 | |
| SCHEMBL11370104 | 0.79 | NPC1 (0.50) | NPC1RAB9AALDH1A1KDM4ELMNA | |
| SCHEMBL9605284 | 0.78 | RAB9A (0.39) | NPC1RAB9AKDM4ELMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4988708-A | 3-Carbamoyl-4-hydroxy-2-carboxylmethyl quinoline analgesics, antiinflammatory agents | ROUSSEL UCLAF (FR) | 1991-01-29 | — | — | US | disclosed |
| US-4845105-A | 4-OH-quinoline carboxylic acid amides having analgesic and anti-inflammatory activity | ROUSSEL UCLAF (FR) | 1989-07-04 | — | — | US | disclosed |
| US-4735951-A | Novel 4-hydroxy-3-quinoline-carboxylates having analgesic and anti-inflammatory activity | ROUSSEL UCLAF (FR) | 1988-04-05 | — | — | US | disclosed |