Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | RARB | P10826 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 3/20 | 0.33 |
| ▸ | ACACA | Q13085 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.32 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10749273 | 0.96 | RARB (0.47) | MAPTRARBTHRBSMN1; SMN2TP53 | |
| SCHEMBL9840871 | 0.94 | RARB (0.48) | MAPTRARBTHRBSMN1; SMN2NPC1 | |
| SCHEMBL9840691 | 0.93 | RARB (0.53) | MAPTRARBTHRBSMN1; SMN2NPC1 | |
| SCHEMBL9840317 | 0.92 | RARB (0.55) | MAPTRARBSMN1; SMN2NPC1RAB9A | |
| SCHEMBL9839372 | 0.92 | RARB (0.55) | MAPTRARBSMN1; SMN2NPC1RAB9A | |
| SCHEMBL9840367 | 0.92 | RARB (0.55) | MAPTRARBSMN1; SMN2NPC1RAB9A | |
| SCHEMBL9839415 | 0.92 | RARB (0.55) | MAPTRARBSMN1; SMN2NPC1RAB9A | |
| SCHEMBL10747027 | 0.92 | RARB (0.55) | MAPTRARBSMN1; SMN2NPC1RAB9A | |
| SCHEMBL9240380 | 0.84 | MAPT (0.50) | MAPTRARBTHRBSMN1; SMN2TP53 | |
| SCHEMBL9357530 | 0.84 | RARB (0.59) | MAPTRARBTHRBSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0220297-B1 | NITROGEN-CONTAINING HETEROCYCLES | MERCK PATENT GmbH (DE) | 1991-12-11 | — | — | EP | disclosed |
| US-4834904-A | FERROELECTRIC LIQUID CRYSTALS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1989-05-30 | — | — | US | disclosed |