⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9380796 | 0.68 | — | — | |
| SCHEMBL6432328 | 0.68 | — | — | |
| SCHEMBL6784491 | 0.60 | — | — | |
| SCHEMBL13019057 | 0.60 | — | — | |
| SCHEMBL2671182 | 0.60 | ITGB2 (0.33) | — | |
| SCHEMBL4741894 | 0.59 | — | — | |
| SCHEMBL19644130 | 0.58 | — | — | |
| SCHEMBL29765349 | 0.56 | — | — | |
| SCHEMBL23460361 | 0.52 | — | — | |
| SCHEMBL218741 | 0.52 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0228094-B1 | Pyrimido[5,4-b][1,4]oxazine derivatives, process for their preparation, medicament containing them and intermediate pyrimido[5,4-b][1,4]oxazine derivatives | CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT. (HU) | 1991-08-14 | — | — | EP | claimed |
| US-12612424-B2 | HPK1 inhibitors and uses thereof | REGOR PHARMACEUTICALS, INC. (US) | 2026-04-28 | — | — | US | disclosed |
| US-20250289799-A1 | PYRIMIDINE COMPOUND, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL USE THEREOF | JIANGSU YAHONG MEDITECH CO., LTD. (CN) | 2025-09-18 | — | — | US | disclosed |
| US-20250163049-A1 | FUSED BICYCLIC HETEROCYCLYL COMPOUNDS AS USP1 INHIBITORS | EXELIXIS INC (US) | 2025-05-22 | — | — | US | disclosed |
| US-20240317775-A1 | H4 Antagonist Compounds | NXERA PHARMA UK LIMITED (GB) | 2024-09-26 | — | — | US | disclosed |
| EP-4396191-A1 | COMPOUNDS USEFUL IN MODULATION OF AHR SIGNALLING | JAGUAHR THERAPEUTICS PTE LTD (SG) | 2024-07-10 | — | — | EP | disclosed |
| US-20240092779-A1 | USP1 INHIBITORS AND USES THEREOF | ZENTAUR THERAPEUTICS USA INC. | 2024-03-21 | — | — | US | disclosed |
| WO-2023033740-A9 | COMPOUNDS USEFUL IN MODULATION OF AHR SIGNALLING | JAGUAHR THERAPEUTICS PTE LTD (SG) | 2023-12-28 | — | — | WO | disclosed |
| WO-2023033740-A1 | COMPOUNDS USEFUL IN MODULATION OF AHR SIGNALLING | JAGUAHR THERAPEUTICS PTE LTD (SG) | 2023-03-09 | — | — | WO | disclosed |
| US-20220389037-A1 | HPK1 INHIBITORS AND USES THEREOF | REGOR PHARMACEUTICALS, INC. | 2022-12-08 | — | — | US | disclosed |
| WO-2022214053-A1 | UBIQUITIN-SPECIFIC PROTEASE 1 (USP1) INHIBITOR | 海南耀臻生物医药科技有限公司 | 2022-10-13 | — | — | WO | disclosed |
| EP-0228094-B1 | Pyrimido[5,4-b][1,4]oxazine derivatives, process for their preparation, medicament containing them and intermediate pyrimido[5,4-b][1,4]oxazine derivatives | CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT. (HU) | 1991-08-14 | — | — | EP | disclosed |
| US-4748175-A | Pyrimido[5,4-B][1,4]oxazine derivatives and pharmaceutical compositions containing them | CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT (HU) | 1988-05-31 | — | — | US | disclosed |
| US-4748175-A | Pyrimido[5,4-B][1,4]oxazine derivatives and pharmaceutical compositions containing them | CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT (HU) | 1988-05-31 | — | — | US | disclosed |
| EP-0228094-A2 | Pyrimido[5,4-b][1,4]oxazine derivatives, process for their preparation, medicament containing them and intermediate pyrimido[5,4-b][1,4]oxazine derivatives | CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT. (HU) | 1987-07-08 | — | — | EP | disclosed |