⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9839672 | 0.68 | — | — | |
| SCHEMBL13019057 | 0.60 | — | — | |
| SCHEMBL2671182 | 0.60 | ITGB2 (0.33) | — | |
| SCHEMBL4499079 | 0.57 | — | — | |
| SCHEMBL23460361 | 0.52 | — | — | |
| SCHEMBL218741 | 0.52 | — | — | |
| SCHEMBL25304193 | 0.52 | MAOA (0.44) | — | |
| SCHEMBL127479 | 0.50 | EGFR (0.50) | — | |
| SCHEMBL23508879 | 0.49 | — | — | |
| SCHEMBL691236 | 0.48 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2408774-B1 | INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE 1(DGAT-1) AND USES THEREOF | METABASIS THERAPEUTICS INC (US) | 2014-11-26 | — | — | EP | disclosed |
| EP-0327284-B1 | Triazolo(1,5-c)pyrimido(1,4) azines as bronchodilators | RIKER LABORATORIES INC (US) | 1994-08-17 | — | — | EP | disclosed |
| US-5166343-A | Chemical intermediates for bronchodilators | RIKER LABORATORIES, INC. (US) | 1992-11-24 | — | — | US | disclosed |
| US-5089493-A | Triazolo[1,5-C]pyrimido[1,4]azines as bronchodilators | RIKER LABORATORIES, INC. (US) | 1992-02-18 | — | — | US | disclosed |
| US-4981850-A | Triazolo[1,5-c]pyrimido[1,4]azines as bronchodilators | RIKER LABORATORIES, INC. (US) | 1991-01-01 | — | — | US | disclosed |
| EP-0327284-A2 | Triazolo(1,5-c)pyrimido(1,4) azines as bronchodilators | RIKER LABORATORIES, INC. (US) | 1989-08-09 | — | — | EP | disclosed |
| US-4451650-A | ANTITUMOR AGENTS | SOUTHERN RESEARCH INSTITUTE (US) | 1984-05-29 | — | — | US | disclosed |
| EP-0107130-A1 | Pyrido(4,3-b)(1,4) oxazines and pyrido(4,3-b) (1,4)thiazines | Southern Research Institute (US) | 1984-05-02 | — | — | EP | disclosed |