Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 16/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 16/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 16/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 16/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 16/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 16/20 | 0.39 |
| ▸ | GABRA6 | Q16445 | 9/20 | 0.38 |
| ▸ | GABRA4 | P48169 | 8/20 | 0.38 |
| ▸ | GABRP | O00591 | 7/20 | 0.38 |
| ▸ | GABRD | O14764 | 7/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 7/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 7/20 | 0.38 |
| ▸ | GABRE | P78334 | 7/20 | 0.38 |
| ▸ | GABRG1 | Q8N1C3 | 7/20 | 0.38 |
| ▸ | GABRG3 | Q99928 | 7/20 | 0.38 |
| ▸ | GABRQ | Q9UN88 | 7/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9839919 | 0.92 | GABRA1 (0.42) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL9840043 | 0.88 | GABRA1 (0.53) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL10631461 | 0.85 | GABRA1 (0.47) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL9838848 | 0.85 | GABRA1 (0.41) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL9838999 | 0.82 | GABRA1 (0.41) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL9840004 | 0.82 | GABRA1 (0.40) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL7500463 | 0.81 | GABRA1 (0.47) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL9839932 | 0.81 | GABRA1 (0.43) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL9840270 | 0.80 | GABRA1 (0.54) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL9840293 | 0.80 | GABRA1 (0.44) | GABRA1GABRG2GABRB3GABRA5GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0222693-B1 | 3-OXADIAZOLYL AND 3-CARBOXYLIC-ACID BETA-CARBOLINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1991-04-17 | — | — | EP | disclosed |