Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.46 |
| ▸ | AHR | P35869 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9120280 | 0.90 | GAA (0.53) | GAALMNAMAPK1POLBKCNK3 | |
| SCHEMBL9376102 | 0.87 | BACE1 (0.55) | GAAPOLBKDM4EMAPK14RAB9A | |
| SCHEMBL9312304 | 0.87 | GSK3B (0.53) | GAAPOLBKCNK3SMN1; SMN2RAB9A | |
| SCHEMBL10477973 | 0.86 | MEN1 (0.56) | GAAPOLBKDM4EMAPK14SMN1; SMN2 | |
| SCHEMBL9312281 | 0.86 | NQO2 (0.51) | MAPK14KMT2A | |
| SCHEMBL15578805 | 0.85 | MAPK14 (0.51) | LMNAKCNK3KDM4EMAPK14SMN1; SMN2 | |
| SCHEMBL10478091 | 0.85 | TRPV1 (0.52) | LMNARAB9ATP53KMT2A | |
| SCHEMBL9840136 | 0.83 | ROCK1 (0.49) | GAATDP1MAPK14HTTL3MBTL1 | |
| SCHEMBL10478082 | 0.82 | KMT2A (0.59) | GAAKDM4ESMN1; SMN2RAB9AKCNK9 | |
| SCHEMBL9840703 | 0.82 | MAPK14 (0.45) | LMNAMAPK14SMN1; SMN2RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4963686-A | INTERMEDIATES FOR INOTROPIC AGENTS | BOEHRINGER MANNHEIM GMBH (DE) | 1990-10-16 | — | — | US | claimed |
| WO-1991001986-A1 | N-(DIALKYLOXOPHOSPHINYLALKYL)-LACTAMS, PROCESS FOR PREPARING THEM AND DRUGS CONTAINING THEM | BOEHRINGER MANNHEIM GMBH (DE) | 1991-02-21 | — | — | WO | disclosed |