Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.44 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.44 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9312253 | 0.89 | ABL1 (0.54) | ROCK1KMT2AROCK2GAAMAPK14 | |
| SCHEMBL9865203 | 0.85 | CRBN (0.47) | ROCK1HTTCYP3A4BAZ2BKMT2A | |
| SCHEMBL9840437 | 0.83 | GAA (0.53) | HTTKMT2AL3MBTL1TDP1GAA | |
| SCHEMBL16324214 | 0.82 | CRBN (0.56) | CYP3A4BAZ2BPDE3BPDE3APDE4A | |
| SCHEMBL9312281 | 0.80 | NQO2 (0.51) | CYP3A4KMT2AMAPK14GSK3B | |
| SCHEMBL10477973 | 0.80 | MEN1 (0.56) | HTTCYP3A4KMT2AMAPTGAA | |
| SCHEMBL9312304 | 0.78 | GSK3B (0.53) | HTTCYP3A4KMT2AMAPTGAA | |
| SCHEMBL22661803 | 0.78 | CYP3A4 (0.64) | ROCK1HTTCYP3A4BAZ2BKMT2A | |
| SCHEMBL9840703 | 0.77 | MAPK14 (0.45) | CYP3A4KMT2AMAPTMAPK14RXFP1 | |
| SCHEMBL10478082 | 0.77 | KMT2A (0.59) | CYP3A4KMT2AMAPTGAAGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991001986-A1 | N-(DIALKYLOXOPHOSPHINYLALKYL)-LACTAMS, PROCESS FOR PREPARING THEM AND DRUGS CONTAINING THEM | BOEHRINGER MANNHEIM GMBH (DE) | 1991-02-21 | — | — | WO | disclosed |