Fluoride

Fluoride

SCHEMBL9841887

CCC12CCC(COc3ccc([S])cc3)(CC1)CC2.CCC12CCC(COc3ccc([S])cc3)(CC1)CC2.CCC12CCC(COc3ccc([S])cc3)(CC1)CC2.CCC12CCC(COc3ccc([S])cc3)(CC1)CC2.CCC12CCC(COc3ccc([S])cc3)(CC1)CC2.F.F.F.F.F

nearest known ligand 0.34

Full drug profile on Sugi Atlas →

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
NQO1 P15559 1/20 0.34
CYP4A11 Q02928 4/20 0.32
CYP4F2 P78329 3/20 0.32
MAPT P10636 1/20 0.32
HSD11B1 P28845 1/20 0.31
HSD11B2 P80365 1/20 0.31
ALDH1A1 P00352 1/20 0.30
HPGD P15428 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Fluoride SCHEMBL9841634 0.87 CYP4F2 (0.33) NQO1CYP4A11CYP4F2MAPTHSD11B1
Fluoride SCHEMBL9842034 0.84 SCN9A (0.35) CYP4A11CYP4F2ALDH1A1
Fluoride SCHEMBL9841332 0.83 SCN9A (0.39) CYP4A11CYP4F2HSD11B1HSD11B2ALDH1A1
Fluoride SCHEMBL9841466 0.82 SCN9A (0.38) CYP4A11CYP4F2HPGD
Fluoride SCHEMBL9841281 0.82 SCN9A (0.38) CYP4A11CYP4F2HPGD
Fluoride SCHEMBL9841564 0.82 SCN9A (0.38) CYP4A11CYP4F2HPGD
SCHEMBL9841890 0.77 NQO1 (0.32) NQO1CYP4A11CYP4F2HSD11B1HSD11B2
SCHEMBL2643038 0.68 NQO1 (0.74) NQO1MAPTALDH1A1HPGD
SCHEMBL13185146 0.68 SMN1; SMN2 (0.41) MAPTALDH1A1HPGD
SCHEMBL15075278 0.67 WDR5 (0.41) CYP4A11CYP4F2HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5055223-A For use in liquid crystal display elements MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1991-10-08 US disclosed