⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL31017472 | 0.97 | — | — | |
| Formic Acid SCHEMBL29225353 | 0.87 | DAO (0.34) | — | |
| Pyridine SCHEMBL29287366 | 0.85 | TSHR (0.36) | — | |
| SCHEMBL536264 | 0.79 | — | — | |
| SCHEMBL79201 | 0.77 | MAOA (0.47) | — | |
| SCHEMBL7172295 | 0.77 | MAOA (0.42) | — | |
| SCHEMBL536114 | 0.75 | — | — | |
| SCHEMBL163556 | 0.74 | — | — | |
| SCHEMBL30532125 | 0.74 | MAOA (0.45) | — | |
| SCHEMBL6284681 | 0.74 | MAOA (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114539241-B | Pleuromutilin derivative containing thiazole-pyridine methyl aromatic heterocyclic quaternary ammonium salt side chain and preparation method and application thereof | 西咸新区沣厚原创医药科技有限公司 | 2024-06-04 | — | — | CN | disclosed |
| CN-114539241-A | Pleuromutilin derivative containing thiazole-picolyl aromatic heterocyclic quaternary ammonium salt side chain and preparation method and application thereof | 陕西科技大学 | 2022-05-27 | — | — | CN | disclosed |
| CN-106715430-B | inhibition of transient receptor potential A1 ion channels | 伊莱利利公司 | 2019-09-17 | — | — | CN | disclosed |
| CN-109651624-A | A kind of high tenacity is freeze proof/heat resistanceheat resistant/antibacterial plant polyphenol nano-cellulose conductive hydrogel preparation method | 福建农林大学 | 2019-04-19 | — | — | CN | disclosed |
| CN-106749268-A | Heteroaryl compound and its application in medicine | 广东东阳光药业有限公司 | 2017-05-31 | — | — | CN | disclosed |
| CN-106715430-A | Inhibition of transient receptor potential A1 ion channels | 海德拉生物科学公司 | 2017-05-24 | — | — | CN | disclosed |
| CN-104024233-B | Anticancer benzopyrazines through inhibition of FGFR kinase | 阿斯特克斯治疗有限公司 | 2017-05-24 | — | — | CN | disclosed |
| CN-104080787-B | Pyrazolo pyrrolidine compound | 诺华股份有限公司 | 2016-09-14 | — | — | CN | disclosed |
| US-9249154-B2 | Compounds and therapeutic use thereof for protein kinase inhibition | WU ZHANGGUI (US) | 2016-02-02 | — | — | US | disclosed |
| US-9249154-B2 | Compounds and therapeutic use thereof for protein kinase inhibition | WU ZHANGGUI (US) | 2016-02-02 | — | — | US | disclosed |
| US-20110009415-A1 | Thienopyridazine Compounds, Their Preparations, Pharmaceutical Compositions And Uses | WU, ZHANGGUI (CN) | 2011-01-13 | — | — | US | disclosed |
| EP-2265608-A2 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2010-12-29 | — | — | EP | disclosed |
| EP-2241569-A1 | THIENOPYRIDAZINE COMPOUNDS, THEIR PREPARATIONS, PHARMACEUTICAL COMPOSITIONS AND USES | Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory (CN) | 2010-10-20 | — | — | EP | disclosed |
| EP-2241569-A1 | THIENOPYRIDAZINE COMPOUNDS, THEIR PREPARATIONS, PHARMACEUTICAL COMPOSITIONS AND USES | Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory (CN) | 2010-10-20 | — | — | EP | disclosed |
| US-20090275585-A1 | Novel Compounds and Therapeutic Use Thereof for Protein Kinase Inhibition | WU ZHANGGUI | 2009-11-05 | — | — | US | disclosed |
| US-20090275585-A1 | Novel Compounds and Therapeutic Use Thereof for Protein Kinase Inhibition | WU ZHANGGUI | 2009-11-05 | — | — | US | disclosed |
| US-20090275585-A1 | Novel Compounds and Therapeutic Use Thereof for Protein Kinase Inhibition | WU ZHANGGUI | 2009-11-05 | — | — | US | disclosed |
| WO-2009111278-A2 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2009-09-11 | — | — | WO | disclosed |
| EP-0993442-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-04-19 | — | — | EP | disclosed |
| WO-1999001428-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-01-14 | — | — | WO | disclosed |