Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 15/20 | 0.65 |
| ▸ | BACE1 | P56817 | 2/20 | 0.65 |
| ▸ | MDH2 | P40926 | 1/20 | 0.54 |
| ▸ | CFTR | P13569 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9844718 | 1.00 | ACHE (0.65) | ACHEBACE1MDH2CFTRMAOA | |
| SCHEMBL9844698 | 0.93 | ACHE (0.65) | ACHEBACE1MAOAMAOB | |
| SCHEMBL9844701 | 0.93 | ACHE (0.65) | ACHEBACE1MAOAMAOB | |
| SCHEMBL9255768 | 0.88 | ACHE (0.64) | ACHEBACE1 | |
| SCHEMBL9255759 | 0.88 | ACHE (0.64) | ACHEBACE1 | |
| SCHEMBL9261580 | 0.87 | ACHE (0.54) | ACHEBACE1 | |
| SCHEMBL9261584 | 0.87 | ACHE (0.54) | ACHEBACE1 | |
| SCHEMBL9259699 | 0.85 | ACHE (0.52) | ACHEBACE1 | |
| SCHEMBL9259697 | 0.85 | ACHE (0.52) | ACHEBACE1 | |
| SCHEMBL9259329 | 0.83 | ACHE (0.64) | ACHEBACE1MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0441517-A2 | Tricyclic amines as novel cholinesterase inhibitors | PFIZER INC. (US) | 1991-08-14 | — | — | EP | claimed |