Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OTC | P00480 | 1/20 | 0.49 |
| ▸ | DDAH1 | O94760 | 4/20 | 0.46 |
| ▸ | NOS2 | P35228 | 6/20 | 0.42 |
| ▸ | NOS1 | P29475 | 6/20 | 0.42 |
| ▸ | NOS3 | P29474 | 4/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | GSR | P00390 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | THPO | P40225 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9845038 | 1.00 | OTC (0.49) | OTCDDAH1NOS2NOS1NOS3 | |
| SCHEMBL9845036 | 1.00 | OTC (0.49) | OTCDDAH1NOS2NOS1NOS3 | |
| SCHEMBL287988 | 0.87 | KDM1A (0.51) | OTCDDAH1NOS2NOS1NOS3 | |
| SCHEMBL18071127 | 0.87 | KDM1A (0.51) | OTCDDAH1NOS2NOS1NOS3 | |
| SCHEMBL21195165 | 0.87 | KDM1A (0.51) | OTCDDAH1NOS2NOS1NOS3 | |
| SCHEMBL14842600 | 0.87 | KDM1A (0.51) | OTCDDAH1NOS2NOS1NOS3 | |
| SCHEMBL4407451 | 0.87 | KDM1A (0.51) | OTCDDAH1NOS2NOS1NOS3 | |
| SCHEMBL13485480 | 0.87 | KDM1A (0.51) | OTCDDAH1NOS2NOS1NOS3 | |
| SCHEMBL15199766 | 0.86 | OTC (0.48) | OTCDDAH1NOS2NOS1NOS3 | |
| SCHEMBL26261505 | 0.83 | MAPT (0.42) | OTCDDAH1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0446699-A1 | Inhibitors of nitric oxide biosynthesis | MERRELL PHARMACEUTICALS INC. (US) | 1991-09-18 | — | — | EP | disclosed |