Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.51 |
| ▸ | OTC | P00480 | 1/20 | 0.49 |
| ▸ | DDAH1 | O94760 | 4/20 | 0.46 |
| ▸ | NOS1 | P29475 | 6/20 | 0.44 |
| ▸ | NOS2 | P35228 | 6/20 | 0.42 |
| ▸ | NOS3 | P29474 | 4/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | GSR | P00390 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13485480 | 1.00 | KDM1A (0.51) | KDM1AOTCDDAH1NOS1NOS2 | |
| SCHEMBL21195165 | 1.00 | KDM1A (0.51) | KDM1AOTCDDAH1NOS1NOS2 | |
| SCHEMBL4407451 | 1.00 | KDM1A (0.51) | KDM1AOTCDDAH1NOS1NOS2 | |
| SCHEMBL14842600 | 1.00 | KDM1A (0.51) | KDM1AOTCDDAH1NOS1NOS2 | |
| SCHEMBL287988 | 1.00 | KDM1A (0.51) | KDM1AOTCDDAH1NOS1NOS2 | |
| SCHEMBL9845038 | 0.87 | OTC (0.49) | OTCDDAH1NOS1NOS2NOS3 | |
| SCHEMBL9845041 | 0.87 | OTC (0.49) | OTCDDAH1NOS1NOS2NOS3 | |
| SCHEMBL9845036 | 0.87 | OTC (0.49) | OTCDDAH1NOS1NOS2NOS3 | |
| SCHEMBL18030908 | 0.87 | KDM1A (0.51) | KDM1AOTCDDAH1NOS1NOS2 | |
| SCHEMBL26431181 | 0.87 | KDM1A (0.51) | KDM1AOTCDDAH1NOS1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220169676-A1 | INHIBITORS OF GROWTH FACTOR ACTIVATION ENZYMES | WASHINGTON UNIVERSITY (US) | 2022-06-02 | — | — | US | disclosed |
| US-11130780-B2 | Inhibitors of growth factor activation enzymes | WASHINGTON UNIVERSITY (US) | 2021-09-28 | — | — | US | disclosed |
| US-20180066015-A1 | INHIBITORS OF GROWTH FACTOR ACTIVATION ENZYMES | WASHINGTON UNIVERSITY (US) | 2018-03-08 | — | — | US | disclosed |
| WO-2016144654-A1 | INHIBITORS OF GROWTH FACTOR ACTIVATION ENZYMES | WASHINGTON UNIVERSITY (US) | 2016-09-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11130780-B2 | Inhibitors of growth factor activation enzymes | HDGF, MMP7, HGF | KDM1A 3570/4885OTC 2660/4885DDAH1 1856/4885 |
| US-20220169676-A1 | INHIBITORS OF GROWTH FACTOR ACTIVATION ENZYMES | HDGF, MMP7, HGF | KDM1A 3570/4885OTC 2660/4885DDAH1 1856/4885 |
| US-20180066015-A1 | INHIBITORS OF GROWTH FACTOR ACTIVATION ENZYMES | HDGF, MMP7, HGF | KDM1A 3570/4885OTC 2660/4885DDAH1 1856/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.