Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 11/20 | 0.56 |
| ▸ | CYP11B2 | P19099 | 11/20 | 0.56 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
| ▸ | FNTA | P49354 | 1/20 | 0.42 |
| ▸ | FNTB | P49356 | 1/20 | 0.42 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 3/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9845223 | 0.87 | CYP11B1 (0.71) | CYP11B1CYP11B2ADRA2CFNTAFNTB | |
| SCHEMBL9263763 | 0.85 | CYP11B1 (0.76) | CYP11B1CYP11B2IDO1CYP19A1 | |
| SCHEMBL7250957 | 0.81 | CYP11B1 (0.52) | CYP11B1CYP11B2ADRA2CFNTAFNTB | |
| SCHEMBL27837252 | 0.78 | CYP11B1 (0.58) | CYP11B1CYP11B2FNTAFNTBYTHDC1 | |
| SCHEMBL3822189 | 0.76 | CYP11B1 (0.57) | CYP11B1CYP11B2IDO1CYP19A1SMN1; SMN2 | |
| SCHEMBL1039674 | 0.76 | CYP11B1 (0.51) | CYP11B1CYP11B2IDO1CYP19A1 | |
| Hydrochloric Acid SCHEMBL6601205 | 0.75 | TAAR1 (0.41) | CYP11B1CYP11B2ADRA2CIDO1 | |
| SCHEMBL1041043 | 0.73 | CYP11B1 (0.53) | CYP11B1CYP11B2FNTAFNTBCYP19A1 | |
| SCHEMBL27837146 | 0.73 | CYP11B1 (0.55) | CYP11B1CYP11B2FNTAFNTBYTHDC1 | |
| SCHEMBL3828919 | 0.73 | CYP11B1 (0.78) | CYP11B1CYP11B2CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5066656-A | Aromatase inhibitor, prevention of biosynthesis of estrogens, treatment of estrogen dependent disorders | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-11-19 | — | — | US | disclosed |
| EP-0426225-A2 | (6,7-dihydro-5H-pyrrolo[1,2-c]-imidazol-5-yl)- and (5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl) substituted 1H-benzotriazole derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-05-08 | — | — | EP | disclosed |