Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 17/20 | 0.57 |
| ▸ | CYP11B2 | P19099 | 17/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3820773 | 0.87 | CYP11B1 (0.76) | CYP11B1CYP11B2HTTSMN1; SMN2LMNA | |
| SCHEMBL9263763 | 0.85 | CYP11B1 (0.76) | CYP11B1CYP11B2CYP19A1IDO1 | |
| SCHEMBL3822319 | 0.84 | CYP11B1 (0.52) | CYP11B1CYP11B2HTTSMN1; SMN2LMNA | |
| Hydrochloric Acid SCHEMBL6927027 | 0.83 | CYP11B1 (0.49) | CYP11B1CYP11B2HTTSMN1; SMN2LMNA | |
| SCHEMBL3828919 | 0.81 | CYP11B1 (0.78) | CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL6929093 | 0.80 | CYP11B1 (0.66) | CYP11B1CYP11B2HTTSMN1; SMN2LMNA | |
| SCHEMBL10795658 | 0.78 | CYP11B1 (0.48) | CYP11B1CYP11B2HTTSMN1; SMN2LMNA | |
| SCHEMBL9845199 | 0.76 | CYP11B1 (0.56) | CYP11B1CYP11B2SMN1; SMN2CYP19A1IDO1 | |
| SCHEMBL9119905 | 0.76 | CYP11B1 (0.59) | CYP11B1CYP11B2CYP19A1IDO1 | |
| SCHEMBL3828183 | 0.75 | CYP11B1 (0.81) | CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009106640-A2 | N-BENZYL IMIDAZOLE DERIVATIVES | MAASTRICHT UNIVERSITY (NL) | 2009-09-03 | — | — | WO | disclosed |
| EP-2095819-A1 | N-benzyl imidazole derivatives and their use as aldosterone synthase inhibitors | Maastricht University (NL) | 2009-09-02 | — | — | EP | disclosed |