Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 2/20 | 0.33 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 7/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.32 |
| ▸ | STK17B | O94768 | 1/20 | 0.32 |
| ▸ | CCNC | P24863 | 1/20 | 0.30 |
| ▸ | CDK8 | P49336 | 1/20 | 0.30 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9845315 | 1.00 | MAPT (0.35) | MAPTHPGDALDH1A1TDP1KDM4E | |
| SCHEMBL9845380 | 0.84 | MAPT (0.33) | MAPTHPGDALDH1A1TDP1KDM4E | |
| SCHEMBL9845376 | 0.84 | MAPT (0.33) | MAPTHPGDALDH1A1TDP1KDM4E | |
| SCHEMBL9845344 | 0.83 | ESR1 (0.40) | MAPTHPGDALDH1A1TDP1KDM4E | |
| SCHEMBL9845347 | 0.83 | ESR1 (0.40) | MAPTHPGDALDH1A1TDP1KDM4E | |
| SCHEMBL9845379 | 0.81 | MAPT (0.34) | MAPTHPGDALDH1A1TDP1KDM4E | |
| SCHEMBL9845374 | 0.81 | MAPT (0.34) | MAPTHPGDALDH1A1TDP1KDM4E | |
| SCHEMBL10409056 | 0.75 | MAPK14 (0.32) | MAPTHPGDALDH1A1PTGS2MAPK14 | |
| SCHEMBL9845362 | 0.74 | HMGCR (0.49) | PGRPTGS2 | |
| SCHEMBL9845366 | 0.74 | HMGCR (0.35) | MAPTHPGDALDH1A1TDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0420266-A2 | Chromene or thiochromene derivatives, process for preparing the same, intermediate therefor, pharmaceutical compositions containing said derivatives and the use of said derivatives | TANABE SEIYAKU CO., LTD. (JP) | 1991-04-03 | — | — | EP | disclosed |