Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 6/20 | 0.47 |
| ▸ | PTPN7 | P35236 | 4/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9308442 | 1.00 | HMGCR (0.47) | HMGCRPTPN7RECQLTDP1TSHR | |
| SCHEMBL5144650 | 0.89 | HMGCR (0.50) | HMGCRPTPN7RECQLTDP1TSHR | |
| SCHEMBL5144648 | 0.89 | HMGCR (0.50) | HMGCRPTPN7RECQLTDP1TSHR | |
| SCHEMBL9157592 | 0.82 | HMGCR (0.46) | HMGCRPTPN7RECQLTDP1SMN1; SMN2 | |
| SCHEMBL4062457 | 0.81 | HMGCR (0.46) | HMGCRPTPN7RECQLTDP1TSHR | |
| SCHEMBL4050543 | 0.81 | LMNA (0.54) | HMGCRPTPN7TSHRLMNASMN1; SMN2 | |
| SCHEMBL1866756 | 0.80 | HMGCR (0.53) | HMGCRPTPN7RECQLTDP1TSHR | |
| SCHEMBL11071499 | 0.80 | HMGCR (0.53) | HMGCRPTPN7RECQLTDP1TSHR | |
| SCHEMBL17027694 | 0.80 | HMGCR (0.53) | HMGCRPTPN7RECQLTDP1TSHR | |
| SCHEMBL11071498 | 0.80 | HMGCR (0.53) | HMGCRPTPN7RECQLTDP1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0454146-A1 | Cytotoxic bicyclo[7.3.1] tridec-4-ene-2,6-diyne compounds and process for the preparation thereof | Bristol-Myers Squibb Company (US) | 1991-10-30 | — | — | EP | disclosed |