Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | PRKDC | P78527 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | PDE3B | Q13370 | 6/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 6/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | GRIN2D | O15399 | 3/20 | 0.43 |
| ▸ | GRIN3B | O60391 | 3/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.43 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.43 |
| ▸ | GRIN2C | Q14957 | 3/20 | 0.43 |
| ▸ | GRIN3A | Q8TCU5 | 3/20 | 0.43 |
| ▸ | BLM | P54132 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL215905 | 0.78 | KDM4E (0.52) | MAPTKDM4EALDH1A1CYP3A4HSD17B10 | |
| SCHEMBL28457504 | 0.75 | KDM4E (0.49) | MAPTKDM4EALDH1A1CYP3A4ALOX15 | |
| SCHEMBL210330 | 0.75 | ALDH1A1 (0.68) | MAPTKDM4EALDH1A1CYP3A4ALOX15 | |
| SCHEMBL10778338 | 0.75 | ALDH1A1 (0.62) | MAPTKDM4EALDH1A1CYP3A4ALOX15 | |
| SCHEMBL29800558 | 0.75 | ALDH1A1 (0.68) | MAPTKDM4EALDH1A1CYP3A4ALOX15 | |
| SCHEMBL9332963 | 0.74 | KDM4E (0.47) | MAPTKDM4ECYP3A4GAAGRIN2D | |
| SCHEMBL9432382 | 0.72 | KDM4E (0.46) | MAPTKDM4EALDH1A1CYP3A4ALOX15 | |
| SCHEMBL27944806 | 0.72 | GRIN2D (0.67) | MAPTCYP3A4ALOX15TDP1GRIN2D | |
| SCHEMBL3294994 | 0.72 | ALDH1A1 (0.59) | MAPTKDM4EALDH1A1CYP3A4ALOX15 | |
| SCHEMBL11251378 | 0.72 | ALDH1A1 (0.55) | MAPTKDM4EALDH1A1CYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0462800-A2 | Inhibitors of HIV reverse transcriptase | MERCK & CO. INC. (US) | 1991-12-27 | — | — | EP | disclosed |
| US-4131677-A | Anti-inflammatory oxazolo [5,4-b]pyridines | MERCK & CO., INC. (US) | 1978-12-26 | — | — | US | disclosed |
| US-4038396-A | ANTIPYRETICS, ANALGESICS | MERCK & CO., INC. (US) | 1977-07-26 | — | — | US | disclosed |