Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | DRD4 | P21917 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9681398 | 0.69 | MAPT (0.51) | MAPTNPC1RAB9ALOXL2TP53 | |
| SCHEMBL9846167 | 0.69 | MAPT (0.48) | MAPTNPC1RAB9ALOXL2TP53 | |
| SCHEMBL155002 | 0.68 | MAPT (1.00) | MAPTNPC1RAB9ALOXL2TP53 | |
| SCHEMBL27748534 | 0.66 | MAPT (0.66) | MAPTNPC1RAB9ALOXL2TP53 | |
| SCHEMBL16067087 | 0.65 | MAPT (0.65) | MAPTNPC1RAB9ALOXL2TP53 | |
| SCHEMBL3125661 | 0.65 | RAB9A (0.59) | MAPTNPC1RAB9ALOXL2TP53 | |
| SCHEMBL27984491 | 0.65 | RAB9A (0.70) | MAPTNPC1RAB9ALOXL2TP53 | |
| SCHEMBL4775028 | 0.64 | NPC1 (0.68) | MAPTNPC1RAB9ALOXL2TP53 | |
| SCHEMBL5573693 | 0.64 | MAPT (0.54) | MAPTNPC1RAB9ALOXL2TP53 | |
| SCHEMBL2123398 | 0.63 | MAPT (0.78) | MAPTNPC1RAB9ALOXL2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0462800-A2 | Inhibitors of HIV reverse transcriptase | MERCK & CO. INC. (US) | 1991-12-27 | — | — | EP | disclosed |