Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GRIA1 | P42261 | 3/20 | 0.41 |
| ▸ | GRIA2 | P42262 | 3/20 | 0.41 |
| ▸ | GRIA3 | P42263 | 3/20 | 0.41 |
| ▸ | GRIA4 | P48058 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.41 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.41 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.41 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL215905 | 0.75 | KDM4E (0.52) | KDM4EGRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL28457504 | 0.73 | KDM4E (0.49) | KDM4EGRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL9332963 | 0.71 | KDM4E (0.47) | KDM4EGRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL9846127 | 0.70 | MAPT (0.47) | KDM4EGRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL9432382 | 0.70 | KDM4E (0.46) | KDM4EGRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL9442192 | 0.69 | GAA (0.45) | KDM4EGRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL9846163 | 0.69 | KDM4E (0.49) | KDM4ECYP3A4TSHRLMNAHPGD | |
| SCHEMBL16958047 | 0.68 | TSHR (0.58) | MAPTCYP3A4TSHRMAPK1GPR35 | |
| SCHEMBL31586887 | 0.68 | TSHR (0.58) | KDM4EMAPTCYP3A4TSHRNPC1 | |
| SCHEMBL7316675 | 0.68 | TSHR (0.40) | KDM4EGRIA1GRIA2GRIA3GRIA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0462800-A2 | Inhibitors of HIV reverse transcriptase | MERCK & CO. INC. (US) | 1991-12-27 | — | — | EP | disclosed |