Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 4/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 11/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 11/20 | 0.38 |
| ▸ | CETP | P11597 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2795401 | 0.82 | ELANE (0.43) | ELANEPIK3CDPIK3CAPIK3CBMAPT | |
| SCHEMBL9846100 | 0.80 | PSMB8 (0.53) | ELANEKDM4EALDH1A1MAPTMTNR1A | |
| SCHEMBL5542790 | 0.79 | ELANE (0.56) | ELANEKDM4EALDH1A1MAPTFAAH | |
| SCHEMBL9846250 | 0.79 | PIK3CD (0.43) | PIK3CDPIK3CBKDM4EALDH1A1MAPT | |
| SCHEMBL21685060 | 0.79 | MAPT (0.40) | ELANEKDM4EALDH1A1MAPTMTNR1A | |
| SCHEMBL14266196 | 0.78 | KMT2A (0.58) | ELANEPIK3CDPIK3CAPIK3CBKDM4E | |
| SCHEMBL755224 | 0.77 | ELANE (0.73) | ELANE | |
| SCHEMBL103297 | 0.76 | PIK3CD (0.39) | ELANEPIK3CDPIK3CAPIK3CBKDM4E | |
| SCHEMBL12355752 | 0.76 | ELANE (0.41) | ELANEALDH1A1FAAHCETP | |
| SCHEMBL22042865 | 0.75 | NUDT1 (0.56) | KDM4EMAPTCETP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0462800-A2 | Inhibitors of HIV reverse transcriptase | MERCK & CO. INC. (US) | 1991-12-27 | — | — | EP | disclosed |