Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | HTR2C | P28335 | 2/20 | 0.44 |
| ▸ | HTR2B | P41595 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6691292 | 0.81 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL6692054 | 0.80 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL6611458 | 0.80 | DRD2 (0.65) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL507518 | 0.80 | NPC1 (0.51) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL2439457 | 0.79 | MAPT (0.56) | ALDH1A1 | |
| SCHEMBL9846882 | 0.79 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DSIGMAR1 | |
| SCHEMBL14784803 | 0.79 | DRD2 (0.63) | PDE4APDE4BPDE4CPDE4DSIGMAR1 | |
| SCHEMBL29171625 | 0.79 | NPC1 (0.56) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2439507 | 0.79 | NPC1 (0.51) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL2437519 | 0.79 | NPC1 (0.51) | PDE4APDE4BPDE4CPDE4DALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0417760-A2 | Phenylalkanoyl substituted imidazo[4,5-c] pyridines | G.D. Searle & Co. (US) | 1991-03-20 | — | — | EP | disclosed |
| US-4988707-A | Platelet activating factor, antiinflammatory agents, cardiovascular disorders and treatment of asthma | G. D. SEARLE & CO. (US) | 1991-01-29 | — | — | US | disclosed |