Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | GRM6 | O15303 | 2/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.39 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.39 |
| ▸ | SLC18A3 | Q16572 | 6/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9847802 | 1.00 | TSHR (0.50) | TSHRNPC1RAB9AHTTGRM6 | |
| SCHEMBL2951485 | 1.00 | TSHR (0.50) | TSHRNPC1RAB9AHTTGRM6 | |
| SCHEMBL1496634 | 1.00 | TSHR (0.50) | TSHRNPC1RAB9AHTTGRM6 | |
| SCHEMBL2951484 | 1.00 | TSHR (0.50) | TSHRNPC1RAB9AHTTGRM6 | |
| SCHEMBL1496695 | 0.98 | NPC1 (0.49) | TSHRNPC1RAB9AHTTGRM6 | |
| SCHEMBL1496672 | 0.96 | TSHR (0.46) | TSHRNPC1RAB9AHTTGRM6 | |
| SCHEMBL1496529 | 0.85 | MMP2 (0.44) | TSHRNPC1RAB9AHTTSMN1; SMN2 | |
| SCHEMBL9264881 | 0.85 | NPC1 (0.43) | TSHRNPC1RAB9AHTTSLC18A3 | |
| SCHEMBL9262067 | 0.85 | NPC1 (0.43) | TSHRNPC1RAB9AHTTSLC18A3 | |
| SCHEMBL9262069 | 0.85 | NPC1 (0.43) | TSHRNPC1RAB9AHTTSLC18A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0415776-A2 | Indolobenzoquinoline derivatives, their preparation and their use as anti-arrhythmic drugs | Sankyo Company Limited (JP) | 1991-03-06 | — | — | EP | disclosed |