Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | USP2 | O75604 | 3/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | BLM | P54132 | 3/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | RECQL | P46063 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | PKM | P14618 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | THRB | P10828 | 2/20 | 0.53 |
| ▸ | RGS12 | O14924 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9847960 | 0.85 | KDM4E (0.49) | KDM4EUSP2HIF1AALOX15HSD17B10 | |
| SCHEMBL3513801 | 0.84 | KDM4E (0.59) | KDM4EUSP2HIF1AALOX15HSD17B10 | |
| SCHEMBL3513799 | 0.84 | KDM4E (0.59) | KDM4EUSP2HIF1AALOX15HSD17B10 | |
| SCHEMBL6046185 | 0.80 | KDM4E (0.57) | KDM4EUSP2HIF1AALOX15HSD17B10 | |
| SCHEMBL9848000 | 0.79 | KDM4E (0.53) | KDM4EUSP2HIF1AALOX15HSD17B10 | |
| SCHEMBL29141538 | 0.78 | KDM4E (0.51) | KDM4EUSP2HIF1AALOX15HSD17B10 | |
| SCHEMBL25471322 | 0.77 | KDM4E (0.54) | KDM4EUSP2HIF1AALOX15HSD17B10 | |
| SCHEMBL27125031 | 0.76 | KDM4E (0.57) | KDM4EUSP2HIF1AALOX15HSD17B10 | |
| SCHEMBL9952323 | 0.76 | KDM4E (0.57) | KDM4EUSP2HIF1AALOX15HSD17B10 | |
| SCHEMBL5324196 | 0.75 | KDM4E (0.51) | KDM4EUSP2HIF1AALOX15HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0451422-A1 | Pharmaceutically active fluoromethyltyrosine compounds | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-10-16 | — | — | EP | claimed |
| EP-0451422-A1 | Pharmaceutically active fluoromethyltyrosine compounds | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-10-16 | — | — | EP | disclosed |