Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.52 |
| ▸ | BLM | P54132 | 2/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.52 |
| ▸ | HTR2A | P28223 | 2/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | HTR2C | P28335 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.52 |
| ▸ | HTR7 | P34969 | 1/20 | 0.52 |
| ▸ | HTR2B | P41595 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9851441 | 1.00 | KDM4E (0.52) | KDM4ECYP3A4ALOX15KMT2AHSD17B10 | |
| SCHEMBL5566266 | 0.88 | KDM4E (0.50) | KDM4ECYP3A4ALOX15KMT2AHSD17B10 | |
| SCHEMBL10932979 | 0.84 | KDM4E (0.52) | KDM4ECYP3A4ALOX15KMT2AHSD17B10 | |
| SCHEMBL10934414 | 0.84 | KDM4E (0.52) | KDM4ECYP3A4ALOX15KMT2AHSD17B10 | |
| SCHEMBL1577675 | 0.81 | USP2 (0.57) | KDM4ECYP3A4ALOX15KMT2AHSD17B10 | |
| SCHEMBL751609 | 0.81 | USP2 (0.57) | KDM4ECYP3A4ALOX15KMT2AHSD17B10 | |
| SCHEMBL12375142 | 0.81 | USP2 (0.57) | KDM4ECYP3A4ALOX15KMT2AHSD17B10 | |
| SCHEMBL24804601 | 0.81 | HSD17B10 (0.43) | KDM4ECYP3A4ALOX15KMT2AHSD17B10 | |
| SCHEMBL2679928 | 0.80 | KDM4E (0.66) | KDM4ECYP3A4ALOX15KMT2AHSD17B10 | |
| SCHEMBL569807 | 0.80 | SLC7A5 (0.58) | KDM4ECYP3A4ALOX15KMT2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0451422-A1 | Pharmaceutically active fluoromethyltyrosine compounds | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-10-16 | — | — | EP | claimed |
| EP-0451422-A1 | Pharmaceutically active fluoromethyltyrosine compounds | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-10-16 | — | — | EP | disclosed |