Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PLAU | P00749 | 3/20 | 0.31 |
| ▸ | PLG | P00747 | 1/20 | 0.31 |
| ▸ | PLAT | P00750 | 1/20 | 0.31 |
| ▸ | USP7 | Q93009 | 1/20 | 0.31 |
| ▸ | USP47 | Q96K76 | 1/20 | 0.31 |
| ▸ | GSK3A | P49840 | 1/20 | 0.30 |
| ▸ | GSK3B | P49841 | 1/20 | 0.30 |
| ▸ | FBP1 | P09467 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9849208 | 0.77 | GRIN2D (0.39) | FDPSPLAU | |
| SCHEMBL9849130 | 0.74 | PLAU (0.38) | ALDH1A1TDP1KDM4EPLAUPLG | |
| SCHEMBL23088349 | 0.73 | USP8 (0.44) | ALDH1A1TDP1KDM4EPOLBUSP7 | |
| SCHEMBL29792782 | 0.73 | USP8 (0.44) | ALDH1A1TDP1KDM4EPOLBUSP7 | |
| SCHEMBL28518453 | 0.73 | USP8 (0.44) | ALDH1A1KDM4EUSP7USP47 | |
| SCHEMBL30576360 | 0.72 | KDM4E (0.36) | ALDH1A1KDM4EPOLB | |
| SCHEMBL15124651 | 0.72 | KDM4E (0.36) | ALDH1A1KDM4EPOLB | |
| SCHEMBL9849240 | 0.69 | POLB (0.39) | FDPSALDH1A1KDM4EPOLBGSK3A | |
| SCHEMBL29358794 | 0.69 | PLAU (0.50) | FDPSALDH1A1KDM4EPOLBPLAU | |
| SCHEMBL251028 | 0.69 | PLAU (0.50) | FDPSALDH1A1KDM4EPOLBPLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0421436-A2 | Substituted carboxytetrahydroisoquinolines and derivatives thereof having pharmaceutical activity | WARNER-LAMBERT COMPANY (US) | 1991-04-10 | — | — | EP | claimed |
| EP-0421436-A2 | Substituted carboxytetrahydroisoquinolines and derivatives thereof having pharmaceutical activity | WARNER-LAMBERT COMPANY (US) | 1991-04-10 | — | — | EP | disclosed |