Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 9/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 4/20 | 0.42 |
| ▸ | RARA | P10276 | 1/20 | 0.38 |
| ▸ | RARB | P10826 | 1/20 | 0.38 |
| ▸ | RARG | P13631 | 1/20 | 0.38 |
| ▸ | RXRB | P28702 | 1/20 | 0.38 |
| ▸ | RXRG | P48443 | 1/20 | 0.38 |
| ▸ | GABRP | O00591 | 1/20 | 0.38 |
| ▸ | GABRD | O14764 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.38 |
| ▸ | GABRE | P78334 | 1/20 | 0.38 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9850161 | 0.91 | RXRA (0.46) | RXRAAKR1B1RARARARBRARG | |
| SCHEMBL8865432 | 0.89 | AKR1B1 (0.39) | RXRAAKR1B1RARARARBRARG | |
| SCHEMBL9850230 | 0.87 | RXRA (0.42) | RXRAAKR1B1GABRPGABRDGABRA1 | |
| SCHEMBL8462110 | 0.82 | RXRA (0.41) | RXRAAKR1B1RARARARBRARG | |
| SCHEMBL8865320 | 0.80 | RXRA (0.41) | RXRAAKR1B1SSTR5CYP26A1CYP26B1 | |
| SCHEMBL9006972 | 0.79 | RARB (0.40) | RXRAAKR1B1RARARARBRARG | |
| SCHEMBL8865693 | 0.78 | RXRA (0.41) | RXRAAKR1B1GABRPGABRDGABRA1 | |
| SCHEMBL9850251 | 0.77 | RXRA (0.56) | RXRARARARARBRARGRXRB | |
| SCHEMBL8865353 | 0.77 | RXRA (0.38) | RXRAAKR1B1GABRPGABRDGABRA1 | |
| SCHEMBL8864927 | 0.76 | RXRA (0.37) | RXRAAKR1B1GABRPGABRDGABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0435681-A1 | Chroman esters of phenols and benzoic acids having retinoid-like activity | ALLERGAN, INC. (US) | 1991-07-03 | — | — | EP | disclosed |
| US-5006550-A | Skin disorder, arthritis, wound healing agents, dry eye syndrome | ALLERGAN, INC. (US) | 1991-04-09 | — | — | US | disclosed |