Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | PDE5A | O76074 | 19/20 | 0.48 |
| ▸ | PDE6C | P51160 | 2/20 | 0.44 |
| ▸ | PDE6D | O43924 | 1/20 | 0.44 |
| ▸ | PDE6A | P16499 | 1/20 | 0.44 |
| ▸ | PDE6G | P18545 | 1/20 | 0.44 |
| ▸ | PDE6B | P35913 | 1/20 | 0.44 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.44 |
| ▸ | PDE1A | P54750 | 1/20 | 0.41 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.41 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.41 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9850804 | 0.85 | PDE5A (0.51) | PDE5APDE6CPDE6DPDE6APDE6G | |
| SCHEMBL147134 | 0.83 | PDE5A (0.69) | MEN1KMT2APDE5APDE6CPDE6D | |
| SCHEMBL2567696 | 0.79 | PDE5A (0.74) | PDE5APDE6CPDE6DPDE6APDE6G | |
| SCHEMBL7726863 | 0.74 | MEN1 (0.64) | MEN1KMT2APDE5APDE6CPDE6D | |
| SCHEMBL7722744 | 0.71 | MEN1 (0.59) | MEN1KMT2APDE5APDE6CPDE6D | |
| SCHEMBL7723392 | 0.71 | MEN1 (0.58) | MEN1KMT2APDE5APDE6CPDE6D | |
| SCHEMBL7723016 | 0.70 | MEN1 (0.60) | MEN1KMT2APDE5APDE6CPDE6D | |
| SCHEMBL7718573 | 0.70 | MEN1 (0.67) | MEN1KMT2APDE5A | |
| SCHEMBL7725988 | 0.69 | PDE5A (0.72) | MEN1KMT2APDE5APDE6CPDE6D | |
| SCHEMBL7721797 | 0.69 | PDE5A (0.69) | MEN1KMT2APDE5APDE6CPDE6D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0442204-A2 | Pyrimidopyrimidine derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1991-08-21 | — | — | EP | claimed |
| EP-0442204-A2 | Pyrimidopyrimidine derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1991-08-21 | — | — | EP | disclosed |