Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | PDE5A | O76074 | 6/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.50 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.50 |
| ▸ | ALPL | P05186 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | GUSB | P08236 | 2/20 | 0.46 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.43 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.43 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.42 |
| ▸ | TNKS | O95271 | 1/20 | 0.42 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.42 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7726863 | 0.89 | MEN1 (0.64) | MEN1KMT2APDE5AGUSB | |
| SCHEMBL147134 | 0.87 | PDE5A (0.69) | MEN1KMT2APDE5A | |
| SCHEMBL7723016 | 0.86 | MEN1 (0.60) | MEN1KMT2APDE5AGUSB | |
| SCHEMBL7722744 | 0.85 | MEN1 (0.59) | MEN1KMT2APDE5AGUSB | |
| SCHEMBL7723392 | 0.84 | MEN1 (0.58) | MEN1KMT2APDE5AGUSB | |
| SCHEMBL7721598 | 0.81 | PDE5A (0.50) | MEN1KMT2APDE5AFGFR1FGFR2 | |
| SCHEMBL7723384 | 0.80 | ALPL (0.51) | MEN1KMT2APDE5AFGFR1FGFR2 | |
| SCHEMBL7726177 | 0.74 | PDE5A (0.70) | MEN1KMT2APDE5AGUSB | |
| SCHEMBL1084872 | 0.73 | GUSB (0.78) | GUSBTNKSTNKS2PARP2 | |
| SCHEMBL29740691 | 0.73 | GUSB (0.78) | GUSBTNKSTNKS2PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0351058-B1 | PYRIMIDOPYRIMIDINE DERIVATIVES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1993-06-02 | — | — | EP | claimed |
| US-6391885-B1 | CONTROLLING APOPTOSIS IN AUTOIMMUNE DISEASE | CELL PATHWAYS, INC. | 2002-05-21 | — | — | US | disclosed |
| US-6060477-A | Method of treating a patient having precancerous lesions with phenyl cycloamino pyrimidinone derivatives | CELL PATHWAYS, INC. (US) | 2000-05-09 | — | — | US | disclosed |
| EP-0351058-B1 | PYRIMIDOPYRIMIDINE DERIVATIVES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1993-06-02 | — | — | EP | disclosed |
| US-5162316-A | Pyrimido[4,5-d]pyrimidine derivatives for use as bronchodilators | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1992-11-10 | — | — | US | disclosed |
| EP-0351058-A1 | Pyrimidopyrimidine derivatives | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1990-01-17 | — | — | EP | disclosed |