Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.62 |
| ▸ | DAO | P14920 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | APEX1 | P27695 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PDE2A | O00408 | 1/20 | 0.42 |
| ▸ | PDE6D | O43924 | 1/20 | 0.42 |
| ▸ | PDE8A | O60658 | 1/20 | 0.42 |
| ▸ | PDE5A | O76074 | 1/20 | 0.42 |
| ▸ | PDE9A | O76083 | 1/20 | 0.42 |
| ▸ | PDE8B | O95263 | 1/20 | 0.42 |
| ▸ | PDE6A | P16499 | 1/20 | 0.42 |
| ▸ | PDE6G | P18545 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9981108 | 0.85 | DAO (0.58) | ALDH1A1KDM4EHPGDDAOHSD17B10 | |
| SCHEMBL10479214 | 0.81 | ALDH1A1 (0.61) | ALDH1A1KDM4EHPGDDAOHSD17B10 | |
| SCHEMBL891521 | 0.81 | DAO (0.55) | ALDH1A1KDM4EHPGDDAOPOLB | |
| Hydrochloric Acid SCHEMBL10479206 | 0.78 | DAO (0.53) | ALDH1A1KDM4EHPGDDAOHSD17B10 | |
| SCHEMBL30615639 | 0.78 | POLB (0.58) | ALDH1A1DAOHSD17B10MAPK1POLB | |
| SCHEMBL7499251 | 0.78 | KDM4E (0.60) | ALDH1A1KDM4EHPGDDAOKMT2A | |
| SCHEMBL24312042 | 0.77 | DAO (0.58) | ALDH1A1KDM4EHPGDDAOKMT2A | |
| SCHEMBL9850691 | 0.77 | DAO (0.55) | ALDH1A1KDM4EHPGDDAOPOLB | |
| SCHEMBL4277542 | 0.77 | KDM4E (0.54) | ALDH1A1KDM4EDAOPDE2APDE6D | |
| SCHEMBL18125932 | 0.77 | ALDH1A1 (1.00) | ALDH1A1KDM4EHPGDHSD17B10MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0416740-A2 | Novel compounds with renin-inhibiting activity | Beecham Group p.l.c. (GB) | 1991-03-13 | — | — | EP | disclosed |