Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 12/20 | 0.59 |
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.51 |
| ▸ | ADRA2A known ✓ | P08913 | 2/20 | 0.51 |
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.51 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.51 |
| ▸ | GRIN2A known ✓ | Q12879 | 1/20 | 0.51 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.48 |
| ▸ | BCHE | P06276 | 10/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.51 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.51 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3562426 | 0.98 | ACHE (0.61) | ACHEBCHEALDH1A1HSD17B10KDM4E | |
| SCHEMBL9851400 | 0.89 | BCHE (0.63) | ACHEBCHEALDH1A1HSD17B10KDM4E | |
| Hydrochloric Acid SCHEMBL9851368 | 0.86 | BCHE (0.61) | ACHEBCHEALDH1A1HSD17B10KDM4E | |
| SCHEMBL5578035 | 0.77 | ACHE (0.57) | ACHEBCHEALDH1A1KDM4EGRIN1 | |
| SCHEMBL9170695 | 0.73 | ACHE (0.62) | ACHEBCHEALDH1A1HSD17B10KDM4E | |
| SCHEMBL9170398 | 0.72 | ACHE (0.53) | ACHEBCHEALDH1A1HSD17B10KDM4E | |
| Water SCHEMBL9851354 | 0.72 | BCHE (0.39) | ACHEBCHEALDH1A1HSD17B10KDM4E | |
| Tacrine SCHEMBL8000475 | 0.70 | ACHE (0.97) | ACHEBCHEALDH1A1HSD17B10KDM4E | |
| SCHEMBL6610838 | 0.70 | ACHE (0.62) | ACHEBCHEALDH1A1HSD17B10KDM4E | |
| SCHEMBL15797635 | 0.70 | BCHE (0.39) | ACHEBCHEALDH1A1HSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0430485-A2 | Quinoline compound | UBE INDUSTRIES, LTD. (JP) | 1991-06-05 | — | — | EP | claimed |
| EP-0430485-A2 | Quinoline compound | UBE INDUSTRIES, LTD. (JP) | 1991-06-05 | — | — | EP | disclosed |