Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 15/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
| ▸ | PDE6C | P51160 | 1/20 | 0.40 |
| ▸ | PDE1A | P54750 | 1/20 | 0.40 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.40 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.40 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7646403 | 0.83 | PDE5A (0.41) | PDE5AMAPTHSD17B10 | |
| SCHEMBL7374277 | 0.82 | PDE5A (0.52) | PDE5AMAPTHSD17B10 | |
| SCHEMBL7648303 | 0.82 | KDM4E (0.43) | PDE5AMAPTHSD17B10 | |
| SCHEMBL149188 | 0.80 | KMT2A (0.48) | PDE5AMAPTHSD17B10PDE6CPDE1A | |
| SCHEMBL7644598 | 0.75 | KDM4E (0.43) | MAPTHSD17B10 | |
| SCHEMBL7645418 | 0.74 | HPGD (0.39) | PDE5AMAPTHSD17B10 | |
| SCHEMBL7645372 | 0.74 | KMT2A (0.53) | PDE5AMAPTPDE6CPDE1APDE1B | |
| SCHEMBL10875693 | 0.72 | TDP1 (0.78) | PDE5AMAPTHSD17B10TDP1RORC | |
| SCHEMBL7368255 | 0.72 | KDM4E (0.51) | PDE5AMAPTHSD17B10PDE6CPDE1A | |
| SCHEMBL2569103 | 0.71 | PDE5A (0.84) | PDE5APDE6CPDE1APDE1BPDE1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0428268-A2 | Pharmaceutical phenylpyridone derivatives | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1991-05-22 | — | — | EP | claimed |
| EP-0428268-A2 | Pharmaceutical phenylpyridone derivatives | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1991-05-22 | — | — | EP | disclosed |