Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B3 | P37058 | 9/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | THPO | P40225 | 1/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.43 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9853289 | 0.99 | HSD17B3 (0.53) | HSD17B3MEN1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL6988456 | 0.84 | HSD17B3 (0.69) | HSD17B3MEN1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL9853254 | 0.80 | GAA (0.39) | MEN1ALDH1A1CYP1A2CYP3A4CYP2D6 | |
| Maleic Acid SCHEMBL9853346 | 0.79 | HRH2 (0.37) | HSD17B3MEN1ALDH1A1CYP1A2CYP3A4 | |
| Fumaric Acid SCHEMBL9853351 | 0.79 | HRH2 (0.37) | HSD17B3MEN1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL5044763 | 0.74 | HSD17B3 (0.60) | HSD17B3NOTUMCYP11B1CYP11B2 | |
| SCHEMBL5044757 | 0.74 | HSD17B3 (0.60) | HSD17B3NOTUMCYP11B1CYP11B2 | |
| SCHEMBL5042877 | 0.72 | HSD17B3 (0.72) | HSD17B3ALOX15NOTUM | |
| SCHEMBL8788236 | 0.72 | HSD17B3 (0.53) | HSD17B3MEN1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL23504300 | 0.69 | HSD17B3 (0.53) | HSD17B3MEN1ALDH1A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0413300-A1 | Pyrido [3,4-b][1,4] benzoxazepines, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-02-20 | — | — | EP | claimed |
| US-4940704-A | Pyrido[3,4-b][1,4]benzoxazepines | HOECHST-ROUSSEL PHARMACEUTICAL INC. (US) | 1990-07-10 | — | — | US | claimed |
| EP-0413300-A1 | Pyrido [3,4-b][1,4] benzoxazepines, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-02-20 | — | — | EP | disclosed |