Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.34 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.33 |
| ▸ | HRH2 | P25021 | 1/20 | 0.37 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | THPO | P40225 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | CCNC | P24863 | 2/20 | 0.33 |
| ▸ | CDK8 | P49336 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9853351 | 1.00 | HRH2 (0.37) | HRH2PTGER1ALDH1A1MEN1MAPT | |
| SCHEMBL9853254 | 0.89 | GAA (0.39) | PTGER1ALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL9853250 | 0.79 | HSD17B3 (0.55) | PTGER1ALDH1A1MEN1MAPTKMT2A | |
| Hydrochloric Acid SCHEMBL9853289 | 0.78 | HSD17B3 (0.53) | PTGER1ALDH1A1MEN1MAPTKMT2A | |
| Fumaric Acid SCHEMBL9853234 | 0.77 | GAA (0.54) | ALDH1A1MEN1MAPTKMT2AKDM4E | |
| Maleic Acid SCHEMBL9853230 | 0.77 | GAA (0.54) | ALDH1A1MEN1MAPTKMT2AKDM4E | |
| SCHEMBL2616327 | 0.73 | MAOA (0.48) | ALDH1A1MEN1MAPTKMT2ACYP1A2 | |
| Maleic Acid SCHEMBL29935486 | 0.71 | HTT (0.50) | HRH2ALDH1A1MEN1MAPTKMT2A | |
| Fumaric Acid SCHEMBL6589279 | 0.69 | GAA (0.45) | ALDH1A1KDM4ESLC6A2 | |
| Maleic Acid SCHEMBL6589272 | 0.69 | GAA (0.45) | ALDH1A1KDM4ESLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0413300-A1 | Pyrido [3,4-b][1,4] benzoxazepines, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-02-20 | — | — | EP | disclosed |
| US-4940704-A | Pyrido[3,4-b][1,4]benzoxazepines | HOECHST-ROUSSEL PHARMACEUTICAL INC. (US) | 1990-07-10 | — | — | US | disclosed |