SCHEMBL9853296

SCHEMBL9853296

COc1cc(N(c2cccc(C)c2)c2cccc(C)c2)cc(N(c2cccc(C)c2)c2cccc(C)c2)c1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE P22303 2/20 0.53
RELA Q04206 1/20 0.42
NPC1 O15118 1/20 0.42
RAB9A P51151 1/20 0.42
MAOB P27338 1/20 0.40
HSD17B1 P14061 7/20 0.39
HSD17B2 P37059 7/20 0.39
CYP3A4 P08684 3/20 0.38
CYP1A2 P05177 2/20 0.38
CYP2C9 P11712 2/20 0.38
CYP2C19 P33261 2/20 0.38
CYP1A1 P04798 1/20 0.38
CYP2E1 P05181 1/20 0.38
CYP2C8 P10632 1/20 0.38
CYP2D6 P10635 1/20 0.38
CYP2A6 P11509 1/20 0.38
CYP4B1 P13584 1/20 0.38
CYP2B6 P20813 1/20 0.38
CYP3A5 P20815 1/20 0.38
CYP2A7 P20853 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8497577 0.91 ACHE (0.67) ACHERELANPC1RAB9AMAOB
SCHEMBL29391727 0.86 ACHE (0.52) ACHENPC1RAB9AHSD17B1HSD17B2
SCHEMBL147931 0.86 ACHE (0.52) ACHENPC1RAB9AHSD17B1HSD17B2
SCHEMBL7875082 0.86 ACHE (0.60) ACHERELANPC1RAB9AMAOB
SCHEMBL14158330 0.85 ACHE (0.53) ACHERELANPC1RAB9AMAOB
SCHEMBL10065391 0.84 NPC1 (0.51) ACHERELANPC1RAB9ACYP3A4
SCHEMBL18350097 0.84 ACHE (0.58) ACHENPC1RAB9AMAOBHSD17B1
SCHEMBL8766625 0.84 ACHE (0.50) ACHENPC1RAB9AHSD17B1HSD17B2
SCHEMBL134721 0.84 ACHE (0.55) ACHENPC1RAB9AHSD17B1HSD17B2
SCHEMBL29692933 0.84 ACHE (0.55) ACHENPC1RAB9AHSD17B1HSD17B2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0455247-A2 m-Phenylenediamine compound and electrophotosensitive material using said compound MITA INDUSTRIAL CO. LTD. (JP) 1991-11-06 EP disclosed