SCHEMBL9853326

SCHEMBL9853326

C[C@@]12CCC[C@H]1[C@@H]1CC=C3C[C@@H](O)CC(OC4CC4)[C@]3(C)[C@H]1CC2

nearest known ligand 0.48

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
SHBG P04278 3/20 0.41
G6PD P11413 3/20 0.39
CYP17A1 P05093 2/20 0.39
TBXAS1 P24557 1/20 0.39
SRD5A2 P31213 1/20 0.39
ESR1 P03372 4/20 0.38
ESR2 Q92731 4/20 0.38
AR P10275 3/20 0.38
SERPINA6 P08185 2/20 0.38
MEN1 O00255 1/20 0.38
LMNA P02545 1/20 0.38
GUSB P08236 1/20 0.38
CYP3A4 P08684 1/20 0.38
PMP22 Q01453 1/20 0.38
KMT2A Q03164 1/20 0.38
GPBAR1 Q8TDU6 1/20 0.38
TSHR P16473 1/20 0.38
NR1I3 Q14994 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3112585 0.84 ESR1 (0.45) SHBGG6PDCYP17A1TBXAS1SRD5A2
SCHEMBL4152712 0.84 ESR1 (0.45) SHBGG6PDCYP17A1TBXAS1SRD5A2
SCHEMBL3112594 0.84 ESR1 (0.45) SHBGG6PDCYP17A1TBXAS1SRD5A2
SCHEMBL6899626 0.83 SHBG (0.44) SHBGG6PDCYP17A1TBXAS1SRD5A2
SCHEMBL7259576 0.78 SHBG (0.41) SHBGG6PDCYP17A1TBXAS1SRD5A2
SCHEMBL23155091 0.75 SHBG (0.64) SHBGG6PDCYP17A1TBXAS1SRD5A2
SCHEMBL11970666 0.75 SHBG (0.64) SHBGG6PDCYP17A1TBXAS1SRD5A2
SCHEMBL14149814 0.75 SHBG (0.64) SHBGG6PDCYP17A1TBXAS1SRD5A2
SCHEMBL336035 0.75 SHBG (0.64) SHBGG6PDCYP17A1TBXAS1SRD5A2
SCHEMBL13461623 0.75 SHBG (0.64) SHBGG6PDCYP17A1TBXAS1SRD5A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0291717-A1 17Beta-(cyclopropyloxy) androst-5-en-3beta-ol and related compounds useful as c 17-20 lyase inhibitors MERRELL DOW PHARMACEUTICALS INC. (US) 1988-11-23 EP claimed
EP-0413269-A2 4-substituted 17-beta-(cyclopropyloxy)androst-5-EN-3-beta-OL and related compounds useful as C17-20 lyase inhibitors MERRELL PHARMACEUTICALS INC. (US) 1991-02-20 EP disclosed