Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 18/20 | 0.65 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.63 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.63 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2107861 | 0.92 | ALOX5AP (0.78) | ALOX5APPTGS1PTGS2ALOX5CYP3A4 | |
| SCHEMBL2108613 | 0.84 | ALOX5AP (0.80) | ALOX5APPTGS1PTGS2ALOX5CYP3A4 | |
| SCHEMBL13920496 | 0.83 | ALOX5AP (0.83) | ALOX5APPTGS1PTGS2ALOX5CYP3A4 | |
| SCHEMBL9853382 | 0.81 | ALOX5AP (0.67) | ALOX5APPTGS1PTGS2ALOX5CYP3A4 | |
| SCHEMBL9048306 | 0.80 | ALOX5AP (0.84) | ALOX5APPTGS1PTGS2ALOX5CYP3A4 | |
| SCHEMBL2108478 | 0.79 | ALOX5AP (1.00) | ALOX5APPTGS1PTGS2ALOX5CYP3A4 | |
| SCHEMBL2108514 | 0.78 | ALOX5AP (0.85) | ALOX5APPTGS1PTGS2ALOX5CYP3A4 | |
| SCHEMBL2108178 | 0.77 | PTGS1 (1.00) | ALOX5APPTGS1PTGS2ALOX5CYP3A4 | |
| SCHEMBL8559592 | 0.77 | ALOX5AP (0.72) | ALOX5APPTGS1PTGS2ALOX5CYP3A4 | |
| SCHEMBL2107877 | 0.77 | PTGS1 (0.86) | ALOX5APPTGS1PTGS2ALOX5CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0419049-A1 | (Quinolin-2-ylmethoxy) indoles as inhibitors of the biosynthesis of leukotrienes | MERCK FROSST CANADA INC. (CA) | 1991-03-27 | — | — | EP | claimed |