Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 6/20 | 0.73 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.73 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.73 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.73 |
| ▸ | PDE1A | P54750 | 1/20 | 0.64 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.64 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.64 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.59 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.59 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11145310 | 0.88 | PDE4A (0.57) | PDE4APDE4BPDE4CPDE4DPDE1A | |
| SCHEMBL11033822 | 0.87 | PDE1A (0.73) | PDE4APDE4BPDE4CPDE4DPDE1A | |
| SCHEMBL29393229 | 0.85 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DADORA2B | |
| SCHEMBL11374959 | 0.84 | PDE1A (0.60) | PDE4APDE4BPDE4CPDE4DPDE1A | |
| SCHEMBL11531219 | 0.83 | ADORA2B (0.78) | PDE4APDE4BPDE4CPDE4DADORA2B | |
| SCHEMBL11004837 | 0.82 | PDE4A (0.73) | PDE4APDE4BPDE4CPDE4DPDE1A | |
| SCHEMBL4471527 | 0.82 | PDE1A (0.67) | PDE4APDE4BPDE4CPDE4DPDE1A | |
| SCHEMBL7089727 | 0.82 | ADORA2B (0.68) | PDE4APDE4BPDE4CPDE4DPDE1A | |
| SCHEMBL27378735 | 0.81 | PDE1A (0.65) | PDE4APDE4BPDE4CPDE4DPDE1A | |
| SCHEMBL11381461 | 0.80 | PDE1A (0.58) | PDE4APDE4BPDE4CPDE4DPDE1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0421587-A2 | Xanthine derivatives used in asthma | Beecham Group p.l.c. (GB) | 1991-04-10 | — | — | EP | claimed |
| EP-0421587-A2 | Xanthine derivatives used in asthma | Beecham Group p.l.c. (GB) | 1991-04-10 | — | — | EP | disclosed |