Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
| ▸ | HTR5A | P47898 | 1/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 5/20 | 0.46 |
| ▸ | ABL1 | P00519 | 4/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.45 |
| ▸ | DHFR | P00374 | 1/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9853594 | 0.87 | CCNC (0.46) | HTR2BHTR5AADORA2AADORA1SRC | |
| Maleic Acid SCHEMBL9853592 | 0.87 | CCNC (0.46) | HTR2BHTR5AADORA2AADORA1SRC | |
| SCHEMBL29419535 | 0.79 | ADORA2A (0.51) | HTR2BHTR5AADORA2AADORA1CYP1A2 | |
| SCHEMBL27843373 | 0.78 | CDK5 (0.45) | HTR2BHTR5AADORA2AADORA1MAPK9 | |
| SCHEMBL4058635 | 0.77 | CDK5 (0.47) | HTR2BHTR5AADORA2AADORA1CYP1A2 | |
| SCHEMBL31695983 | 0.77 | MAPKAPK2 (0.45) | HTR2BHTR5AADORA2AADORA1CYP1A2 | |
| SCHEMBL19432619 | 0.77 | ALK (0.45) | HTR2BHTR5AADORA2AADORA1SRC | |
| SCHEMBL729774 | 0.75 | HTR2B (0.59) | HTR2BHTR5AADORA2AADORA1CYP1A2 | |
| SCHEMBL29445836 | 0.75 | HTR2B (0.59) | HTR2BHTR5AADORA2AADORA1CYP1A2 | |
| SCHEMBL18703800 | 0.73 | DYRK1A (0.57) | CYP1A2SRCABL1MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0405426-A2 | Naphthylamino- and naphthyloxy-pyridinamines and related compounds, a process for their preparation and their use as dermatological agents | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-01-02 | — | — | EP | disclosed |