SCHEMBL729774

SCHEMBL729774

c1ccc2cc(-c3nccc4ccccc34)ccc2c1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR2B P41595 1/20 0.59
HTR5A P47898 1/20 0.59
MAPK9 P45984 2/20 0.51
MAPK10 P53779 2/20 0.51
MAPK8 P45983 1/20 0.51
KDM4E B2RXH2 4/20 0.50
NPC1 O15118 3/20 0.50
RAB9A P51151 3/20 0.50
MAPT P10636 3/20 0.50
L3MBTL1 Q9Y468 2/20 0.50
KMT2A Q03164 2/20 0.50
GLA P06280 1/20 0.50
NPSR1 Q6W5P4 1/20 0.50
GPR55 Q9Y2T6 1/20 0.46
F2 P00734 1/20 0.46
NPY5R Q15761 1/20 0.46
CYP2A6 P11509 1/20 0.46
F12 P00748 1/20 0.46
PLAU P00749 1/20 0.46
NCF1 P14598 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29445836 1.00 HTR2B (0.59) HTR2BHTR5AMAPK9MAPK10MAPK8
SCHEMBL15977567 0.89 HTR2B (0.50) HTR2BHTR5AMAPK9MAPK10MAPK8
SCHEMBL17944664 0.89 HTR2B (0.50) HTR2BHTR5AMAPK9MAPK10MAPK8
SCHEMBL12580390 0.89 HTR2B (0.49) HTR2BHTR5AMAPK9MAPK10MAPK8
SCHEMBL12580331 0.89 HTR2B (0.49) HTR2BHTR5AMAPK9MAPK10MAPK8
SCHEMBL24662625 0.88 HTR2B (0.51) HTR2BHTR5AMAPK9MAPK10MAPK8
SCHEMBL13169307 0.88 HTR2B (0.58) HTR2BHTR5AMAPK9MAPK10MAPK8
SCHEMBL17343231 0.87 HTR2B (0.48) HTR2BHTR5AMAPK9MAPK10MAPK8
SCHEMBL12451881 0.86 HTR2B (0.47) HTR2BHTR5AMAPK9MAPK10MAPK8
SCHEMBL12112873 0.86 MAPT (0.58) HTR2BHTR5AKDM4ENPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7727690-B2 Iridium complex, carbazole derivatives and copolymer having the same GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2010-06-01 US claimed
EP-1923385-B1 Iridium complex, carbazole derivatives and copolymer having the same KWANGJU INST SCI & TECH (KR) 2009-05-27 EP claimed
US-20080177084-A1 IRIDIUM COMPLEX, CARBAZOLE DERIVATIVES AND COPOLYMER HAVING THE SAME GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2008-07-24 US claimed
EP-1923385-A1 Iridium complex, carbazole derivatives and copolymer having the same Gwangju Institute of Science and Technology (KR) 2008-05-21 EP claimed
US-20230337520-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2023-10-19 US disclosed
US-20230250118-A1 ELECTROLUMINESCENT MATERIAL AND DEVICE THEREOF Beijing Summer Sprout Technology Co., Ltd. (CN) 2023-08-10 US disclosed
US-20220402877-A1 ELECTROLUMINESCENT DEVICE Beijing Summer Sprout Technology Co., Ltd. (CN) 2022-12-22 US disclosed
EP-3660934-A1 ORGANIC LIGHT EMITTING ELEMENT CAPABLE OF DRIVING AT LOW VOLTAGE AND HAVING HIGH EFFICIENCY AND LONG LIFE CHARACTERISTICS SFC Co., Ltd. (KR) 2020-06-03 EP disclosed
CN-110139869-A Diphosphine metal carbonyl complexes, preparation method and application method 香港大学 2019-08-16 CN disclosed
US-20180362565-A1 METHOD FOR PRODUCING CYCLOMETALATED IRIDIUM COMPLEX TANAKA KIKINZOKU KOGYO K.K. (JP) 2018-12-20 US disclosed
US-10053479-B2 Raw material and production method for cyclometalated iridium complex TANAKA KIKINZOKU KOGYO K.K. (JP) 2018-08-21 US disclosed
US-20180072753-A1 NOVEL ORGANIC HETEROCYCLIC COMPOUND AND LIGHT-EMITTING DEVICE COMPRISING SAME SFC CO., LTD. (KR) 2018-03-15 US disclosed
US-20100317858-A1 METAL COORDINATION COMPOUND AND LIGHT-EMITTING MATERIAL CONTAINING THE SAME NATIONAL INSTITUTE OF ADVANCE INDUSTRIAL SCIENCE AND TECHNOLOGY (JP) 2010-12-16 US disclosed
US-7727690-B2 Iridium complex, carbazole derivatives and copolymer having the same GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2010-06-01 US disclosed
US-20100120810-A1 COMPOUNDS AND METHODS FOR MODULATING RHO GTPASES EXONHIT THERAPEUTICS SA (FR) 2010-05-13 US disclosed
EP-1923385-B1 Iridium complex, carbazole derivatives and copolymer having the same KWANGJU INST SCI & TECH (KR) 2009-05-27 EP disclosed
US-20080177084-A1 IRIDIUM COMPLEX, CARBAZOLE DERIVATIVES AND COPOLYMER HAVING THE SAME GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2008-07-24 US disclosed
EP-1923385-A1 Iridium complex, carbazole derivatives and copolymer having the same Gwangju Institute of Science and Technology (KR) 2008-05-21 EP disclosed
US-20070178332-A1 highly efficient phosphorescent organometallic complex and an organic electroluminescent (EL) device using the same. The organometallic complex can be used in the formation of an organic layer of the organic EL device, and can emit red light from phosphorescent material SAMSUNG DISPLAY CO., LTD. (KR) 2007-08-02 US disclosed
US-20070178332-A1 highly efficient phosphorescent organometallic complex and an organic electroluminescent (EL) device using the same. The organometallic complex can be used in the formation of an organic layer of the organic EL device, and can emit red light from phosphorescent material SAMSUNG DISPLAY CO., LTD. (KR) 2007-08-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220402877-A1 ELECTROLUMINESCENT DEVICE MCOLN2, MCOLN1, LDHB HTR2B 1393/4885HTR5A 3086/4885MAPK9 2280/4885
US-20180362565-A1 METHOD FOR PRODUCING CYCLOMETALATED IRIDIUM COMPLEX PRKCA, PRKACG, PRKACB HTR2B 3196/4885HTR5A 1077/4885MAPK9 1630/4885
US-20180072753-A1 NOVEL ORGANIC HETEROCYCLIC COMPOUND AND LIGHT-EMITTING DEVICE COMPRISING SAME OR10J3, CRY1, NR2E3 HTR2B 1155/4885HTR5A 1493/4885MAPK9 2751/4885
US-20100120810-A1 COMPOUNDS AND METHODS FOR MODULATING RHO GTPASES RAC1, RAC2, RAC3 HTR2B 2968/4885HTR5A 3922/4885MAPK9 1604/4885
US-20230250118-A1 ELECTROLUMINESCENT MATERIAL AND DEVICE THEREOF CRY1, LEF1, PIEZO1 HTR2B 3337/4885HTR5A 4238/4885MAPK9 351/4885
US-20080177084-A1 IRIDIUM COMPLEX, CARBAZOLE DERIVATIVES AND COPOLYMER HAVING THE SAME INTS9, HIRIP3, HELZ HTR2B 691/4885HTR5A 173/4885MAPK9 2133/4885
US-20230337520-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES LBR, LPO, LPL HTR2B 2046/4885HTR5A 4314/4885MAPK9 1601/4885
US-20100317858-A1 METAL COORDINATION COMPOUND AND LIGHT-EMITTING MATERIAL CONTAINING THE SAME CRY1, SOD1, L1CAM HTR2B 3452/4885HTR5A 4113/4885MAPK9 459/4885
US-10053479-B2 Raw material and production method for cyclometalated iridium complex DTYMK, IPO5, IPMK HTR2B 4395/4885HTR5A 2320/4885MAPK9 3757/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.