Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 2/20 | 0.40 |
| ▸ | RARG | P13631 | 2/20 | 0.40 |
| ▸ | RARA | P10276 | 1/20 | 0.40 |
| ▸ | HSPA9 | P38646 | 4/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1450895 | 0.86 | RARB (0.40) | RARBRARGRARAHSPA9KDM1A | |
| SCHEMBL6755319 | 0.81 | HTR2A (0.31) | AR | |
| SCHEMBL30993810 | 0.73 | KDM1A (0.53) | RARBRARGRARAHSPA9KDM1A | |
| SCHEMBL397152 | 0.73 | KDM1A (0.53) | RARBRARGRARAHSPA9KDM1A | |
| SCHEMBL2014128 | 0.72 | RXRA (0.33) | RARBRARGRARA | |
| SCHEMBL3714772 | 0.69 | RARB (0.50) | RARBRARGRARAHSPA9KDM1A | |
| SCHEMBL816209 | 0.68 | — | — | |
| SCHEMBL19859121 | 0.68 | RARB (0.49) | RARBRARGRARAHSPA9KDM1A | |
| SCHEMBL9057990 | 0.68 | RARB (0.49) | RARBRARGRARAHSPA9KDM1A | |
| SCHEMBL1396642 | 0.68 | RARB (0.49) | RARBRARGRARAHSPA9AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0263492-B1 | RETINOIDS, THEIR PREPARATION AND USE AS PHARMACEUTICAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 1991-03-13 | — | — | EP | disclosed |
| US-4900478-A | SKIN DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1990-02-13 | — | — | US | disclosed |
| EP-0263492-A1 | Retinoids, their preparation and use as pharmaceutical compounds | F. HOFFMANN-LA ROCHE AG (CH) | 1988-04-13 | — | — | EP | disclosed |